Myochrysine (Gold Sodium Thiomalate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Myochrysine

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Rheumatoid arthritis is an autoimmune disease that can cause chronic inflammation of the joints and other areas of the body.
Rheumatoid arthritis can affect people of all ages.
The cause of rheumatoid arthritis is not known.
Rheumatoid arthritis is a chronic disease, characterized by periods of disease flares and remissions.
In rheumatoid arthritis, multiple joints are usually, but not always, affected in a symmetrical pattern.
Chronic inflammation of rheumatoid arthritis can cause permanent joint destruction and deformity.
Damage to joints can occur early and does not correlate with the severity of symptoms.
The "rheumatoid factor" is an antibody that can be found in the blood of 80% of people with rheumatoid arthritis.
There is no known cure for rheumatoid arthritis.
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MYOCHRYSINE®
(gold sodium thiomalate) Injection, USP, 50 mg/mL

Physicians planning to use Gold Sodium Thiomalate should thoroughly familiarize themselves with its toxicity and its benefits. The possibility of toxic reactions should always be explained to the patient before starting therapy. Patients should be warned to report promptly any symptoms suggesting toxicity. Before each injection of Gold Sodium Thiomalate, the physician should review the results of laboratory work, and see the patient to determine the presence or absence of adverse reactions since some of these can be severe or even fatal.

DRUG DESCRIPTION

Gold Sodium Thiomalate is a sterile aqueous solution. It contains 0.5 percent BENZYL alcohol added as a preservative. The pH of the product is 5.8 to 6.5.

Gold Sodium Thiomalate is a mixture of the mono- and di-sodium salts of gold thiomalic acid. The structural formula is:

mercaptobutanedioic acid, monogold (1+) sodium salt

The molecular weight for C₄H₃AuNa₂O₄S (the disodium salt) is 390.07 and for C₄H₄AuNaO₄S (the mono-sodium salt) is 368.09.

Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL.

What are the possible side effects of gold sodium thiomalate (Myochrysine)?

Stop taking gold sodium thiomalate and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Rarely, other serious side effects may also occur. Call your doctor immediately if you experience any of the following:

itching or a rash;
a sore mouth, indigestion, or a metallic taste in the mouth;
severe or bloody diarrhea;
easy bruising or a nosebleed;

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What are the precautions when taking gold sodium thiomalate (Myochrysine)?

Before using gold sodium thiomalate injection, tell your doctor or pharmacist if you are allergic to it; or to any other gold or heavy metal compound; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of reaction to gold compound (e.g., blood disorders, kidney problems, lung problems, severe rash, stomach/intestinal problems), SLE (systemic lupus erythematosus).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (e.g.,...

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Last reviewed on RxList: 11/25/2008
This monograph has been modified to include the generic and brand name in many instances.