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Myochrysine

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Myochrysine

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MYOCHRYSINE®
(gold sodium thiomalate) Injection, USP, 50 mg/mL

Physicians planning to use Gold Sodium Thiomalate should thoroughly familiarize themselves with its toxicity and its benefits. The possibility of toxic reactions should always be explained to the patient before starting therapy. Patients should be warned to report promptly any symptoms suggesting toxicity. Before each injection of Gold Sodium Thiomalate, the physician should review the results of laboratory work, and see the patient to determine the presence or absence of adverse reactions since some of these can be severe or even fatal.

DRUG DESCRIPTION

Gold Sodium Thiomalate is a sterile aqueous solution. It contains 0.5 percent BENZYL alcohol added as a preservative. The pH of the product is 5.8 to 6.5.

Gold Sodium Thiomalate is a mixture of the mono- and di-sodium salts of gold thiomalic acid. The structural formula is:

MYOCHRYSINE (Gold Sodium Thiomalate) Structural Formula Illustration

mercaptobutanedioic acid, monogold (1+) sodium salt

The molecular weight for C4H3AuNa2O4S (the disodium salt) is 390.07 and for C4H4AuNaO4S (the mono-sodium salt) is 368.09.

Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL.

What are the possible side effects of gold sodium thiomalate (Myochrysine)?

Stop taking gold sodium thiomalate and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Rarely, other serious side effects may also occur. Call your doctor immediately if you experience any of the following:

  • itching or a rash;
  • a sore mouth, indigestion, or a metallic taste in the mouth;
  • severe or bloody diarrhea;
  • easy bruising or a nosebleed;
  • ...

Read All Potential Side Effects and See Pictures of Myochrysine »

What are the precautions when taking gold sodium thiomalate (Myochrysine)?

Before using gold sodium thiomalate injection, tell your doctor or pharmacist if you are allergic to it; or to any other gold or heavy metal compound; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of reaction to gold compound (e.g., blood disorders, kidney problems, lung problems, severe rash, stomach/intestinal problems), SLE (systemic lupus erythematosus).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (e.g.,...

Read All Potential Precautions of Myochrysine »

Last reviewed on RxList: 11/25/2008
This monograph has been modified to include the generic and brand name in many instances.

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