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(gold sodium thiomalate) Injection, USP, 50 mg/mL

Physicians planning to use Gold Sodium Thiomalate should thoroughly familiarize themselves with its toxicity and its benefits. The possibility of toxic reactions should always be explained to the patient before starting therapy. Patients should be warned to report promptly any symptoms suggesting toxicity. Before each injection of Gold Sodium Thiomalate, the physician should review the results of laboratory work, and see the patient to determine the presence or absence of adverse reactions since some of these can be severe or even fatal.


Gold Sodium Thiomalate is a sterile aqueous solution. It contains 0.5 percent BENZYL alcohol added as a preservative. The pH of the product is 5.8 to 6.5.

Gold Sodium Thiomalate is a mixture of the mono- and di-sodium salts of gold thiomalic acid. The structural formula is:

MYOCHRYSINE (Gold Sodium Thiomalate) Structural Formula Illustration

mercaptobutanedioic acid, monogold (1+) sodium salt

The molecular weight for C4H3AuNa2O4S (the disodium salt) is 390.07 and for C4H4AuNaO4S (the mono-sodium salt) is 368.09.

Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL.

What are the possible side effects of gold sodium thiomalate (Myochrysine)?

Stop taking gold sodium thiomalate and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Rarely, other serious side effects may also occur. Call your doctor immediately if you experience any of the following:

  • itching or a rash;
  • a sore mouth, indigestion, or a metallic taste in the mouth;
  • severe or bloody diarrhea;
  • easy bruising or a nosebleed;
  • yellow skin or eyes;
  • abdominal...

Read All Potential Side Effects and See Pictures of Myochrysine »

Last reviewed on RxList: 11/25/2008
This monograph has been modified to include the generic and brand name in many instances.


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