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Neurotoxic reactions similar to those observed with penicillin G may arise with intravenous doses of nafcillin especially in patients with concomitant hepatic insufficiency and renal dysfunction (see PRECAUTIONS).

In the case of overdosage, discontinue nafcillin, treat symptomatically and institute supportive measures as required. Hemodialysis does not increase the rate of clearance of nafcillin from the blood.

A history of a hypersensitivity (anaphylactic) reaction to any penicillin is a contraindication.

Solutions containing dextrose may be contraindicated in patients with known allergy to corn or corn products.

Last reviewed on RxList: 11/18/2011
This monograph has been modified to include the generic and brand name in many instances.