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NAMENDA (memantine hydrochloride) is indicated for the treatment of moderate to severe dementia of the Alzheimer's type.


The recommended starting dose of NAMENDA is 5 mg once daily. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice daily), 15 mg/day (5 mg and 10 mg as separate doses), and 20 mg/day (10 mg twice daily). The minimum recommended interval between dose increases is one week. The dosage shown to be effective in controlled clinical trials is 20 mg/day.

NAMENDA can be taken with or without food. If a patient misses a single dose of NAMENDA, that patient should not double up on the next dose. The next dose should be taken as scheduled. If a patient fails to take NAMENDA for several days, dosing may need to be resumed at lower doses and retitrated as described above.

Do not mix NAMENDA oral solution with any other liquid. The oral solution is administered with a dosing device that comes with the drug and consists of a syringe, syringe adaptor cap, tubing and other supplies a patient needs to administer the drug. The supplied syringe should be used to withdraw the correct volume of oral solution and the oral solution should be slowly squirted into the corner of the patient's mouth.

Special Populations

Renal Impairment

A target dose of 5 mg twice daily is recommended in patients with severe renal impairment (creatinine clearance of 5 – 29 mL/min based on the Cockroft-Gault equation).

Hepatic Impairment

NAMENDA should be administered with caution to patients with severe hepatic impairment [see CLINICAL PHARMACOLOGY].


Dosage Forms And Strengths

NAMENDA 5 mg tablet: capsule-shaped, film-coated tablets are tan, with the strength (5) debossed on one side and FL on the other.

NAMENDA 10 mg tablet: capsule-shaped, film-coated tablets are gray, with the strength (10) debossed on one side and FL on the other.

NAMENDA 2 mg/mL oral solution: clear, alcohol-free, sugar-free, and peppermint flavored.

Storage And Handling

5 mg Tablet

Tan, capsule-shaped, film-coated tablets with “5” debossed on one side and FL on the other.

Bottle of 60 NDC #0456-3205-60 10 x 10
Unit Dose NDC #0456-3205-63

10 mg Tablet

Gray, capsule-shaped, film-coated tablets with “10” debossed on one side and FL on the other.

Bottle of 60 NDC #0456-3210-60 10 x 10
Unit Dose NDC #0456-3210-63
Titration Pack: NDC #0456-3200-14

Blister package containing 49 tablets (28 x 5 mg and 21 x 10 mg tablets).

Oral Solution

2 mg/mL Oral Solution (10 mg = 5 mL)
12 fl. oz. (360 mL) bottle NDC #0456-3202-12

Store Namenda tablets and oral solution at 25°C (77°F); excursions permitted to 15-30°C (5986°F) [see USP Controlled Room Temperature].

Manufactured for: Forest Pharmaceuticals, Inc. Subsidiary of Forest Laboratories, Inc. St. Louis, MO 63045. Manufactured by: Forest Laboratories Ireland Ltd. Revised: October 2013

Last reviewed on RxList: 11/18/2013
This monograph has been modified to include the generic and brand name in many instances.


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