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Narcan

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Narcan

NARCAN®
(naloxone hydrochloride) Injection, USP

Opioid Antagonist

DRUG DESCRIPTION

NARCAN (naloxone hydrochloride injection, USP), an opioid antagonist, is a synthetic congener of oxymorphone. In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group.

NARCAN® (Naloxone Hydrochloride) Structural Formula Illustration

Naloxone hydrochloride occurs as a white to slightly off-white powder, and is soluble in water, in dilute acids, and in strong alkali; slightly soluble in alcohol; practically insoluble in ether and in chloroform.

NARCAN (naloxone) injection is available as a sterile solution for intravenous, intramuscular and subcutaneous administration in three concentrations: 0.02 mg, 0.4 mg and 1 mg of naloxone hydrochloride per mL. pH is adjusted to 3.5 ± 0.5 with hydrochloric acid.

The 0.02 mg/mL strength is an unpreserved, paraben-free formulation containing 9 mg/mL sodium chloride.

The 0.4 mg/mL vial contains 8.6 mg/mL of sodium chloride and 2 mg/mL of methylparaben and propylparaben as preservatives in a ratio of 9:1. The 0.4 mg/mL ampul is also available in an unpreserved, paraben-free formulation containing 9 mg/mL of sodium chloride.

The 1 mg/mL vial contains 8.35 mg/mL of sodium chloride and 2 mg/mL of methylparaben and propylparaben as preservatives in a ratio of 9:1. The 1 mg/mL ampul is also available in an unpreserved, paraben-free formulation containing 9 mg/mL of sodium chloride.

What are the possible side effects of naloxone (Narcan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • chest pain, fast or irregular heartbeats;
  • dry cough, wheezing, feeling short of breath;
  • sweating, severe nausea or vomiting;
  • severe headache, agitation, anxiety, confusion, ringing in your ears;
  • seizure (convulsions);
  • feeling like you might pass out; or
  • slow heart rate, weak pulse, fainting, slow...

Read All Potential Side Effects and See Pictures of Narcan »

Last reviewed on RxList: 3/20/2009
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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