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(mometasone furoate monohydrate) Nasal Spray 50 mcg†
†Calculated on the anhydrous basis
Mometasone furoate monohydrate, the active component of NASONEX (mometasone furoate nasal spray) Nasal Spray, 50 mcg, is an anti-inflammatory corticosteroid having the chemical name, 9,21-Dichloro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione17-(2 furoate) monohydrate, and the following chemical structure:
Mometasone furoate monohydrate is a white powder, with an empirical formula of C27H30Cl2O6•H2O, and a molecular weight of 539.45. It is practically insoluble in water; slightly soluble in methanol, ethanol, and isopropanol; soluble in acetone and chloroform; and freely soluble in tetrahydrofuran. Its partition coefficient between octanol and water is greater than 5000.
NASONEX (mometasone furoate nasal spray) Nasal Spray 50 mcg is a metered-dose, manual pump spray unit containing an aqueous suspension of mometasone furoate monohydrate equivalent to 0.05% w/w mometasone furoate calculated on the anhydrous basis; in an aqueous medium containing glycerin, microcrystalline cellulose and carboxymethylcellulose sodium, sodium citrate, citric acid, benzalkonium chloride, and polysorbate 80. The pH is between 4.3 and 4.9.
What are the possible side effects of mometasone nasal (Nasonex)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- severe or ongoing nose bleed;
- sores in the nose that won't heal;
- wheezing, trouble breathing;
- vision problems; or
- fever, chills, body aches, flu symptoms.
Less serious side effects may include:
- stuffy nose, sore throat, cough;
- muscle or joint...
What are the precautions when taking mometasone furoate (nasal spray) (Nasonex)?
Before using mometasone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (such as glaucoma, cataracts), infections (including tuberculosis, herpes eye infection), recent nose problems (such as injury, ulcers, surgery).
Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.
Rarely, using corticosteroid medications for a long time can make...
Last reviewed on RxList: 3/7/2011
This monograph has been modified to include the generic and brand name in many instances.
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