May 30, 2017
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Natazia Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking dienogest and estradiol (Natazia)?

This medication can cause birth defects. Do not use if you are pregnant. Tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking dienogest and estradiol.

You should not take dienogest and estradiol if you have:

  • untreated or uncontrolled high blood pressure;
  • heart disease (coronary artery disease, uncontrolled heart valve disorder, history of heart attack, stroke, or blood clot);
  • a blood-clotting disorder or circulation problems;
  • problems with your eyes, kidneys or circulation caused by diabetes;
  • a history of hormone-related cancer such as breast or uterine cancer;
  • unusual vaginal bleeding that has not been checked by a doctor;
  • liver disease or liver cancer;
  • severe migraine headaches (with aura, numbness, weakness, or vision changes), especially if you are older than 35;
  • a history of jaundice caused by pregnancy or birth control pills; or
  • if you smoke and are over 35 years old.

To make sure you can safely take dienogest and estradiol, tell your doctor if you have any of these other conditions:

  • high blood pressure, high cholesterol or triglycerides, or if you are overweight;
  • a history of depression;
  • underactive thyroid, diabetes;
  • gallbladder disease;
  • seizures or epilepsy; or
  • a history of fibrocystic breast disease, lumps, nodules, or an abnormal mammogram.

The hormones in dienogest and estradiol can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast feeding a baby.

How should I take dienogest and estradiol (Natazia)?

This medication contains 5 different colors of pills. Take 1 pill each day in the exact order directed on the blister pack. Use a back-up birth control, such as condoms or a spermicide, for the first 9 days when you first start using this medication. Do not take two different kinds of birth control pills at the same time.

If you are switching from another birth control pill, start taking dienogest and estradiol on the first day of your withdrawal bleeding. If you were taking progestin-only pills, start taking dienogest and estradiol on the day you would have taken your next pill.

If you are switching from a birth control implant, intrauterine device (IUD), vaginal ring, or skin patch, start taking dienogest and estradiol on the day the other birth control device is removed.

If you are switching from a birth control injection, start taking dienogest and estradiol on the day you would have received your next scheduled injection.

You may have breakthrough bleeding. Tell your doctor if this bleeding continues or is very heavy. You may also have very little or no bleeding during your periods.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medication for a short time. Any doctor or surgeon who treats you should know that you are using dienogest and estradiol.

Store this medication at room temperature away from moisture and heat.

Side Effects Centers

Natazia - User Reviews

Natazia User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Natazia sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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