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Overdose with NATRECOR® therapy has been reported and is primarily the result of either a miscalculated NATRECOR® dose or a mechanical error such as an infusion-pump malfunction or an infusion-pump programming error. The most frequently reported adverse event reported with NATRECOR® overdose is hypotension, which may be symptomatic and may persist for several hours. Asymptomatic hypotensive events may resolve with drug stoppage. In some cases hypotension may persist for several hours beyond discontinuation. In the event of an overdose, discontinue NATRECOR® and support blood pressure [see WARNINGS AND PRECAUTIONS].


NATRECOR® is contraindicated in patients with:

  • Persistent systolic blood pressure < 100 mm Hg prior to therapy because of an increased risk of symptomatic hypotension [see WARNINGS AND PRECAUTIONS]
  • Known hypersensitivity to any of its components [see WARNINGS AND PRECAUTIONS]
  • Cardiogenic shock
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 9/4/2012


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