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Overdose with Natrecor (nesiritide) therapy has been reported and is primarily the result of either a miscalculated Natrecor (nesiritide) dose or a mechanical error such as an infusion-pump malfunction or an infusion-pump programming error. The most frequently reported adverse event reported with Natrecor (nesiritide) overdose is hypotension, which may be asymptomatic and most often resolves with drug stoppage, although in some cases hypotension may persist for several hours beyond discontinuation.. Treatment of Natrecor (nesiritide) overdose should include drug discontinuation and the administration of supportive measures (See PRECAUTIONS – Cardiovascular).

Natrecor (nesiritide) is contraindicated in patients who are hypersensitive to any of its components. Natrecor (nesiritide) should not be used as primary therapy for patients with cardiogenic shock or in patients with a systolic blood pressure < 90 mm Hg.

Last reviewed on RxList: 7/7/2009
This monograph has been modified to include the generic and brand name in many instances.