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home > drugs a-z list > navelbine (vinorelbine tartrate) drug center > navelbine (vinorelbine tartrate) drug - overdosage and contraindications
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Navelbine
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OVERDOSE
There is no known antidote for overdoses of NAVELBINE (vinorelbine tartrate) . Overdoses involving quantities up to 10 times the recommended dose (30 mg/m2) have been reported. The toxicities described were consistent with those listed in the ADVERSE REACTIONS section including paralytic ileus, stomatitis, and esophagitis. Bone marrow aplasia, sepsis, and paresis have also been reported. Fatalities have occurred following overdose of NAVELBINE (vinorelbine tartrate) . If overdosage occurs, general supportive measures together with appropriate blood transfusions, growth factors, and antibiotics should be instituted as deemed necessary by the physician.
CONTRAINDICATIONS
Administration of NAVELBINE (vinorelbine tartrate) is contraindicated in patients with pretreatment granulocyte counts < 1,000 cells/mm3 (see WARNINGS).
Last reviewed on RxList: 12/17/2008
This monograph has been modified to include the generic and brand name in many instances.
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