April 28, 2017
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(pentamidine isethionate)


NebuPent (pentamidine isethionate), an antifungal agent, is a nonpyrogenic lyophilized product. After reconstitution with Sterile Water for Injection, USP, NebuPent (pentamidine isethionate) is administered by inhalation via the Respirgard® II nebulizer [Marquest, Englewood, CO] (see DOSAGE AND ADMINISTRATION).

Pentamidine isethionate, 4,4'-[1,5-pentane-diylbis(oxy)]bis-benzenecarboximidamid, is a white crystalline powder soluble in water and glycerin and insoluble in ether, acetone, and chloroform.

NebuPent ® (pentamidine isethionate) Structural Formula Illustration

C19H24N4O2•2C2H6O4S            592.68

Each vial contains 300 mg pentamidine isethionate.

What are the possible side effects of pentamidine (Nebupent, Pentam 300)?

Side effects with pentamidine are not common. Serious side effects include:

  • an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting);
  • blurred vision;
  • chest pain or irregular heart beat;
  • difficulty breathing;
  • dizziness, confusion, fainting spells or excessive tiredness;
  • drastic appetite changes;
  • pain or irritation at the injection site;
  • mouth ulcers or irritations;
  • severe stomach pain;
  • bleeding or bruising;
  • severe...

Read All Potential Side Effects and See Pictures of Nebupent »

What are the precautions when taking pentamidine isethionate (Nebupent)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor, respiratory therapist, or pharmacist your medical history, especially of: bleeding/blood disorders, breathing problems (such as asthma), diabetes, kidney disease, liver problems, smoking.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs,...

Read All Potential Precautions of Nebupent »

Last reviewed on RxList: 3/7/2017
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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