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Neo-Fradin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/26/2016

Neo-Fradin (neomycin sulfate) Oral Solution is an antibiotic used as adjunctive therapy in hepatic coma by reduction of the ammonia forming bacteria in the intestinal tract. Common side effects of Neo-Fradin include:

The recommended dose of Neo-Fradin is 4-12 grams per day, taken in divided doses. Protein should be withdrawn from the diet and the use of diuretic agents should be avoided. Treatment should be continued over a period of five to six days during which time protein should be returned incrementally to the diet. Oral Neo-Fradin may interact with penicillin V, oral vitamin B-12, methotrexate and 5-fluorourcil, and digoxin. Tell your doctor all medications you use. This drug can cause fetal harm when administered to a pregnant woman. Talk to your doctor about using Neo-Fradin during pregnancy, or if you become pregnant while taking this drug. Because of the potential for harm to nursing infants consult your doctor before breastfeeding. A risk of hearing loss continues after drug withdrawal.

Our Neo-Fradin (neomycin sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Neo-Fradin in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • hearing problems, ringing in your ears, or a feeling of fullness in the ears;
  • spinning sensation, nausea, feeling like you might pass out;
  • loss of balance or coordination, trouble walking;
  • numbness or tingly feeling under your skin;
  • muscle twitching, seizure (convulsions);
  • urinating less than usual or not at all;
  • drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;
  • swelling, weight gain, feeling short of breath;
  • weak or shallow breathing; or
  • severe stomach cramps, diarrhea that is watery or bloody.

Less serious side effects may include:

  • mild nausea, vomiting; or
  • mild diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Neo-Fradin (Neomycin Sulfate)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Neo-Fradin FDA Prescribing Information: Side Effects
(Adverse Reactions)


The most common adverse reactions to oral neomycin are nausea, vomiting, and diarrhea. The “Malabsorption Syndrome” characterized by increased fecal fat, decreased serum carotene and fall in xylose absorption has been reported with prolonged therapy. Nephrotoxicity, ototoxicity, and neuromuscular blockage have been reported ( see BOXED WARNINGS AND PRECAUTIONS section).

Read the entire FDA prescribing information for Neo-Fradin (Neomycin Sulfate)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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