Neo-Synephrine (Phenylephrine Hydrochloride Ophthalmic Solution) Drug Information: Clinical Pharmacology

Pill Identifier Search

May 27, 2012

Neo-Synephrine

High Blood Pressure »

High blood pressure facts

High blood pressure (hypertension) is designated as either essential (primary) hypertension or secondary hypertension and is defined as a consistently elevated blood pressure exceeding 140/90 mm Hg.
High blood pressure is called "the silent killer" because it often causes no symptoms for many years, even decades, until it finally damages certain critical organs.
Poorly controlled high blood pressure ultimately can cause damage to blood vessels in the eye, thickening of the heart muscle and heart attacks, hardening of the arteries (arteriosclerosis), kidney failure, and strokes.
Most antihypertensive medications can be used alone or in combination. Some are used only in combination. Some are preferred over others in certain specific medical situations. And some are not to be used (contraindicated) in other situations.
Several classes of antihypertensive medications are available, including ACE i...

Read the High Blood Pressure article »

« Previous
1
2
3
4
5
6
7
8
9
10
Next »

Neo-Synephrine

Heart Disease Slideshow Pictures

Medical Illustrations of the Heart Image Collection

Take the Heart Disease Quiz!

font size

CLINICAL PHARMACOLOGY

NEO-SYNEPHRINE (phenylephrine hydrochloride ophthalmic solution) possesses predominantly α-adrenergic effects. In the eye, phenylephrine acts locally as a potent vasoconstrictor and mydriatic, by constricting ophthalmic blood vessels and the radial muscle of the iris.

The ophthalmologic usefulness of NEO-SYNEPHRINE (phenylephrine hydrochloride ophthalmic solution) hydrochloride is due to its rapid effect and moderately prolonged action, as well as to the fact that it produces no compensatory vasodilatation.

The action of different concentrations of ophthalmic solutions of NEO-SYNEPHRINE (phenylephrine hydrochloride ophthalmic solution) hydrochloride is shown in the following table:

Strength of solution (%)	Mydriasis		Paralysis of accomodation
Strength of solution (%)	Maximal (minutes)	Recovery time (hours)	Paralysis of accomodation
2.5	15-60	3	trace
10	10-60	6	slight

Although rare, systemic absorption of sufficient quantities of phenylephrine may lead to systemic α-adrenergic effects, such as rise in blood pressure which may be accompanied by a reflex atropine-sensitive bradycardia.

Last reviewed on RxList: 5/6/2008
This monograph has been modified to include the generic and brand name in many instances.