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Neo-Synephrine Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 12/2/2015

Neo-Synephrine (phenylephrine hydrochloride ophthalmic solution) is a vasoconstrictor (constricts the veins) and mydriatic (dilates the pupils), and the over-the-counter strength is used to relieve redness, burning, irritation, and dryness of the eye caused by wind, sun, and other minor irritants. Prescription-strength Neo-Synephrine is used to constrict blood vessels in the eye and to dilate (make bigger) the pupil for conditions such as glaucoma, before surgery, and before eye examinations. Neo-Synephrine is available in generic form. Common side effects of Neo-Synephrine include burning, stinging, pain, increased redness of the eye, tearing or blurred vision, headache, tremor, nausea, sweating, nervousness, dizziness, drowsiness, dryness in the nose, runny nose, and sneezing.

The dose of Neo-Synephrine depends on the condition being treated. Neo-Synephrine may interact with monoamine oxidase inhibitors (MAOIs) or beta-blockers. Talk to your doctor before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products. It is not known whether Neo-Synephrine will be harmful to a fetus. Talk to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether this medication passes into breast milk. Consult your doctor before breastfeeding.

Our Neo-Synephrine (phenylephrine hydrochloride ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Neo-Synephrine in Detail - Patient Information: Side Effects

If you experience any of the following serious side effects, stop using phenylephrine ophthalmic and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; or hives);
  • an irregular or fast heart rate; or
  • high blood pressure (severe headache, blurred vision, or flushed skin).

Other, less serious side effects may be more likely to occur. Continue to use phenylephrine ophthalmic and talk to your doctor if you experience

  • burning, stinging, pain, or increased redness of the eye;
  • tearing or blurred vision;
  • headache;
  • tremor;
  • nausea;
  • sweating;
  • nervousness;
  • dizziness; or
  • drowsiness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Neo-Synephrine (Phenylephrine Hydrochloride Ophthalmic Solution)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Neo-Synephrine FDA Prescribing Information: Side Effects
(Adverse Reactions)


No information provided.

Read the entire FDA prescribing information for Neo-Synephrine (Phenylephrine Hydrochloride Ophthalmic Solution)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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