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Neodecadron

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Neodecadron

NEODECADRON®
(neomycin sulfate-dexamethasone sodium phosphate) Sterile Ophthalmic Solution

Neodecadron

DRUG DESCRIPTION

Ophthalmic Solution NEODECADRON (Neomycin Sulfate-Dexamethasone Sodium Phosphate) is a topical corticosteroid-antibiotic solution for ophthalmic use.

Dexamethasone sodium phosphate is 9-fluoro-11β 17-dihydroxy-16α-methyl-21-(phosphonooxy)pregna-1, 4-diene-3, 20-dione disodium salt. Its empirical formula is C22H28FNa2O8P and its structural formula is:

Dexamethasone sodium phosphate Structural Formula Illustration

Dexamethasone is a synthetic analog of naturally occurring glucocorticoids (hydrocortisone and cortisone).

Dexamethasone sodium phosphate is a water soluble, inorganic ester of dexamethasone. Its molecular weight is 516.41.

Neomycin sulfate, an antibiotic of the aminoglycoside group, is a mixture of the sulfate salts of neomycin, produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae). Neomycin is a complex typically containing 8-13% neomycin C, less than 0.2% neomycin A, and the rest, neomycin B. The empirical formula for both neomycin B and neomycin C is C23H46N6O13, and the molecular weight for each is 614.65. Neomycin A (also referred to as neamine) has an empirical formula of C12H26N4O6 and a molecular weight of 322.36. The structural formulae for neomycin sulfate are:

Neomycin sulfate Structural Formula Illustration

Each milliliter of buffered Ophthalmic Solution NEODECADRON (neomycin and dexamethasone) in the OCUMETER* ophthalmic dispenser contains: dexamethasone sodium phosphate equivalent to 1 mg (0.1%) dexamethasone phosphate, and neomycin sulfate equivalent to 3.5 mg neomycin base. Inactive ingredients: creatinine, sodium citrate, sodium borate, polysorbate 80, disodium edetate, hydrochloric acid to adjust pH to 6.6 -7.2, and water for injection. Benzalkonium chloride 0.02% and sodium bisulfite 0.1% added as preservatives.

What are the possible side effects of neomycin and dexamethasone ophthalmic ()?

Serious side effects are not expected with this medication.

Some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Neodecadron »

Last reviewed on RxList: 2/24/2009
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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