Ophthalmic Solution NEODECADRON (Neomycin Sulfate-Dexamethasone Sodium Phosphate) is a topical corticosteroid-antibiotic solution for ophthalmic use.

Dexamethasone sodium phosphate is 9-fluoro-11β 17-dihydroxy-16α-methyl-21-(phosphonooxy)pregna-1, 4-diene-3, 20-dione disodium salt. Its empirical formula is C₂₂H₂₈FNa₂O₈P and its structural formula is:

Dexamethasone is a synthetic analog of naturally occurring glucocorticoids (hydrocortisone and cortisone).

Dexamethasone sodium phosphate is a water soluble, inorganic ester of dexamethasone. Its molecular weight is 516.41.

Neomycin sulfate, an antibiotic of the aminoglycoside group, is a mixture of the sulfate salts of neomycin, produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae). Neomycin is a complex typically containing 8-13% neomycin C, less than 0.2% neomycin A, and the rest, neomycin B. The empirical formula for both neomycin B and neomycin C is C₂₃H₄₆N₆O₁₃, and the molecular weight for each is 614.65. Neomycin A (also referred to as neamine) has an empirical formula of C₁₂H₂₆N₄O₆ and a molecular weight of 322.36. The structural formulae for neomycin sulfate are:

Each milliliter of buffered Ophthalmic Solution NEODECADRON (neomycin and dexamethasone) in the OCUMETER^* ophthalmic dispenser contains: dexamethasone sodium phosphate equivalent to 1 mg (0.1%) dexamethasone phosphate, and neomycin sulfate equivalent to 3.5 mg neomycin base. Inactive ingredients: creatinine, sodium citrate, sodium borate, polysorbate 80, disodium edetate, hydrochloric acid to adjust pH to 6.6 -7.2, and water for injection. Benzalkonium chloride 0.02% and sodium bisulfite 0.1% added as preservatives.

Last reviewed on RxList: 2/24/2009
This monograph has been modified to include the generic and brand name in many instances.