Neoral (Cyclosporine) Drug Information: Overdosage and Contraindications

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May 27, 2012

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Rheumatoid Arthritis »

Rheumatoid arthritis (RA) facts

Rheumatoid arthritis is an autoimmune disease that can cause chronic inflammation of the joints and other areas of the body.
Rheumatoid arthritis can affect people of all ages.
The cause of rheumatoid arthritis is not known.
Rheumatoid arthritis is a chronic disease, characterized by periods of disease flares and remissions.
In rheumatoid arthritis, multiple joints are usually, but not always, affected in a symmetrical pattern.
Chronic inflammation of rheumatoid arthritis can cause permanent joint destruction and deformity.
Damage to joints can occur early and does not correlate with the severity of symptoms.
The "rheumatoid factor" is an antibody that can be found in the blood of 80% of people with rheumatoid arthritis.
There is no known cure for rheumatoid arthritis.
The treatment of rheumato...

Read the Rheumatoid Arthritis article »

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OVERDOSE

There is a minimal experience with cyclosporine overdosage. Forced emesis and gastric lavage can be of value up to 2 hours after administration of Neoral® (cyclosporine) . Transient hepatotoxicity and nephrotoxicity may occur which should resolve following drug withdrawal. Oral doses of cyclosporine up to 10 g (about 150 mg/kg) have been tolerated with relatively minor clinical consequences, such as vomiting, drowsiness, headache, tachycardia and, in a few patients, moderately severe, reversible impairment of renal function. However, serious symptoms of intoxication have been reported following accidental parenteral overdosage with cyclosporine in premature neonates. General supportive measures and symptomatic treatment should be followed in all cases of overdosage. Cyclosporine is not dialyzable to any great extent, nor is it cleared well by charcoal hemoperfusion. The oral dosage at which half of experimental animals are estimated to die is 31 times, 39 times, and >54 times the human maintenance dose for transplant patients (6mg/kg; corrections based on body surface area) in mice, rats, and rabbits.

CONTRAINDICATIONS

General

Neoral® (cyclosporine) is contraindicated in patients with a hypersensitivity to cyclosporine or to any of the ingredients of the formulation.

Rheumatoid Arthritis

Rheumatoid arthritis patients with abnormal renal function, uncontrolled hypertension, or malignancies should not receive Neoral® (cyclosporine) .

Psoriasis

Psoriasis patients who are treated with Neoral® (cyclosporine) should not receive concomitant PUVA or UVB therapy, methotrexate or other immunosuppressive agents, coal tar or radiation therapy. Psoriasis patients with abnormal renal function, uncontrolled hypertension, or malignancies should not receive Neoral® (cyclosporine) .

Last reviewed on RxList: 10/14/2009
This monograph has been modified to include the generic and brand name in many instances.