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Neosporin Ophthalmic Ointment

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Neosporin Ophthalmic Ointment

NEOSPORIN® Ophthalmic Ointment Sterile
(neomycin and polymyxin B sulfates and bacitracin zinc) Ophthalmic Ointment, USP)

DRUG DESCRIPTION

NEOSPORIN Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) (neomycin and polymyxin B sulfates and bacitracin zinc ophthalmic ointment) is a sterile antimicrobial ointment for ophthalmic use. Each gram contains: neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B units, bacitracin zinc equivalent to 400 bacitracin units, and white petrolatum, q.s.

Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae). It has a potency equivalent of not less than 600 g of neomycin standard per mg, calculated on an anhydrous basis. The structural formulae are:

Neomycin sulfate Structural Formula Illustration

Polymyxin B sulfate is the sulfate salt of polymyxin B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae). It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formulae are:

Polymyxin B sulfate Structural Formula Illustration

Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic polypeptides (mainly bacitracin A) produced by the growth of an organism of the licheniformis group of Bacillus subtilis var Tracy. It has a potency of not less than 40 bacitracin units per mg. The structural formula is:

Bacitracin zinc Structural Formula Illustration

What are the possible side effects of gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic, Ocu-Spore-G)?

Serious side effects are not expected with this medication.

Commonly, some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling or crusting, tearing, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Neosporin Ophthalmic Ointment »

What are the precautions when taking neomycin, polymyxin and bacitracin zinc ophthalmic ointment (Neosporin Ophthalmic Ointment)?

Before using this medication, tell your doctor or pharmacist if you are allergic to neomycin, bacitracin, or polymyxin; or to aminoglycoside antibiotics (e.g., gentamicin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and...

Read All Potential Precautions of Neosporin Ophthalmic Ointment »

Last reviewed on RxList: 9/9/2008
This monograph has been modified to include the generic and brand name in many instances.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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