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Neostigmine Methylsulfate Injection, USP is the dimethylcarbamate of (m-hydroxyphenyl) trimethylammonium methylsulfate.

The structural formula is:

C₁₃H₂₂N₂O₆S............................Molecular Weight 334.40

Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) , an anticholinesterase agent, is a bitter tasting, white crystalline powder and is very soluble in water and soluble in alcohol. Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) Injection, USP is a sterile, nonpyrogenic solution intended for intramuscular, subcutaneous or slow intravenous use.

Each mL of the 1:1000 concentration contains Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) 1 mg, Methylparaben 1.8 mg and Propylparaben 0.2 mg (used as preservatives), in Water for Injection q.s.pH (range 5.0 - 6.5) adjusted, when necessary, with Sodium Hydroxide.

Each mL of the 1:2000 concentration contains Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) 0.5 mg, Methylparaben 1.8 mg and Propylparaben 0.2 mg (used as preservatives), in Water for Injection q.s.pH (range 5.0 - 6.5) adjusted, when necessary, with Sodium Hydroxide.

Last reviewed on RxList: 6/26/2008
This monograph has been modified to include the generic and brand name in many instances.