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The following additional adverse reactions have been reported following the use of either Neostigmine Bromide or Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) .
Allergic: Allergic reactions and anaphylaxis.
Cardiovascular: Cardiac arrhythmias (including bradycardia, tachycardia, A-V block and nodal rhythm) and nonspecific EKG changes have been reported, as well as cardiac arrest, syncope and hypotension.These have been predominantly noted following the use of the injectable form of Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) .
Genitourinary: Urinary frequency.
Miscellaneous: Diaphoresis, flushing and weakness.
Read the Neostigmine Methylsulfate (neostigmine methylsulfate injection) Side Effects Center for a complete guide to possible side effects »
Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) Injection, USP does not antagonize, and may in fact prolong, the Phase 1 block of depolarizing muscle relaxants such as succinylcholine or decamethonium. Certain antibiotics, especially neomycin, streptomycin and kanamycin, have a mild but definite non-depolarizing blocking action which may accentuate neuromuscular block.These antibiotics should be used in the myasthenic patient only where definitely indicated, and then careful adjustment should be made of the anticholinesterase dosage. Local and some general anesthetics, antiarrhythmic agents and other drugs that interfere with neuromuscular transmission should be used cautiously, if at all, in patients with myasthenia gravis;the dose of Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) may have to be increased accordingly.
Last reviewed on RxList: 6/26/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Neostigmine Methylsulfate Information
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