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Neostigmine

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Neostigmine Methylsulfate

Side Effects
Interactions

SIDE EFFECTS

Side effects are generally due to an exaggeration of pharmacological effects of which salivation and fasciculation are the most common.Bowel cramps and diarrhea may also occur.

The following additional adverse reactions have been reported following the use of either Neostigmine Bromide or Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) .

Allergic: Allergic reactions and anaphylaxis.

Neurologic: Dizziness, convulsions, loss of consciousness, drowsiness, headache, dysarthria, miosis and visual changes.

Cardiovascular: Cardiac arrhythmias (including bradycardia, tachycardia, A-V block and nodal rhythm) and nonspecific EKG changes have been reported, as well as cardiac arrest, syncope and hypotension.These have been predominantly noted following the use of the injectable form of Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) .

Respiratory: Increased oral, pharyngeal and bronchial secretions, dyspnea, respiratory depression, respiratory arrest and bronchospasm.

Dermatologic: Rash and urticaria.

Gastrointestinal: Nausea, emesis, flatulence and increased peristalsis.

Genitourinary: Urinary frequency.

Musculoskeletal: Muscle cramps and spasms, arthralgia.

Miscellaneous: Diaphoresis, flushing and weakness.

Read the Neostigmine Methylsulfate (neostigmine methylsulfate injection) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) Injection, USP does not antagonize, and may in fact prolong, the Phase 1 block of depolarizing muscle relaxants such as succinylcholine or decamethonium. Certain antibiotics, especially neomycin, streptomycin and kanamycin, have a mild but definite non-depolarizing blocking action which may accentuate neuromuscular block.These antibiotics should be used in the myasthenic patient only where definitely indicated, and then careful adjustment should be made of the anticholinesterase dosage. Local and some general anesthetics, antiarrhythmic agents and other drugs that interfere with neuromuscular transmission should be used cautiously, if at all, in patients with myasthenia gravis;the dose of Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) may have to be increased accordingly.

Read the Neostigmine Methylsulfate Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 6/26/2008
This monograph has been modified to include the generic and brand name in many instances.

Side Effects
Interactions
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Additional Neostigmine Methylsulfate Information

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