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Neostigmine

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Neostigmine Methylsulfate

Neostigmine Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Neostigmine methylsulfate injection is used to treat myasthenia gravis, postoperative distention and urinary retention, and to reverse effects of non-depolarizing neuromuscular blocking agents after surgery. It is an anticholinesterase agent. Common side effects include salivation, muscle twitching, bowel cramps, or diarrhea.

Dosage of neostigmine methylsulfate injection depends on the condition being treated. Neostigmine methylsulfate injection may interact with muscle relaxants, antibiotics, local and some general anesthetics, or antiarrhythmics. Tell your doctor all medications and supplements you use. During pregnancy, neostigmine methylsulfate injection should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our neostigmine methylsulfate injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Neostigmine FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Side effects are generally due to an exaggeration of pharmacological effects of which salivation and fasciculation are the most common.Bowel cramps and diarrhea may also occur.

The following additional adverse reactions have been reported following the use of either Neostigmine Bromide or Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) .

Allergic: Allergic reactions and anaphylaxis.

Neurologic: Dizziness, convulsions, loss of consciousness, drowsiness, headache, dysarthria, miosis and visual changes.

Cardiovascular: Cardiac arrhythmias (including bradycardia, tachycardia, A-V block and nodal rhythm) and nonspecific EKG changes have been reported, as well as cardiac arrest, syncope and hypotension.These have been predominantly noted following the use of the injectable form of Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) .

Respiratory: Increased oral, pharyngeal and bronchial secretions, dyspnea, respiratory depression, respiratory arrest and bronchospasm.

Dermatologic: Rash and urticaria.

Gastrointestinal: Nausea, emesis, flatulence and increased peristalsis.

Genitourinary: Urinary frequency.

Musculoskeletal: Muscle cramps and spasms, arthralgia.

Miscellaneous: Diaphoresis, flushing and weakness.

Read the entire FDA prescribing information for Neostigmine (Neostigmine Methylsulfate Injection) »

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Additional Neostigmine Methylsulfate Information

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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