April 29, 2016
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Neotrace-4 Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Neotrace-4 (zinc, copper, manganese, chromium) is a solution of four trace elements for use as an additive for total parenteral nutrition in neonates, to help maintain plasma levels of zinc, copper, manganese and chromium and to prevent depletion of endogenous stores of these trace elements and subsequent deficiency symptoms. This medication may be available in generic form. Side effects are uncommon; consult your doctor.

The suggested dosage ranges for the four trace elements in Neotrace-4 in neonates and pediatric patients are: Zinc: For full term infants and children up to 5 years of age, 100 mcg zinc/kg/day. For premature infants up to 3 kg in body weight, 300 mcg zinc/kg/day. Copper: For pediatric patients, the additive dosage level is 20 mcg copper/kg/day. Manganese: For pediatric patients, a dosage of 2 to 10 mcg manganese/kg/day. Chromium: For pediatric patients, the additive dosage is 0.14 to 0.20 mcg/kg/day. Neotrace-4 may interact with other drugs. Tell your doctor all medications and supplements your child uses. During pregnancy, Neotrace-4 should be given only if prescribed. Consult your doctor before breastfeeding.

Our Neotrace-4 (zinc, copper, manganese, chromium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Neotrace-4 FDA Prescribing Information: Side Effects
(Adverse Reactions)


The amounts of zinc, copper, chromium and manganese in Neotrace®-4 are very small and toxicity symptoms due to these trace elements at suggested dosage levels are considered unlikely to occur.

Drug Abuse and Dependence

None known.

Read the entire FDA prescribing information for Neotrace-4 (Metal-4 Combination (for Neonates))

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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