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- Clinician Information:
Nephramine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
5.4% NephrAmine (essential amino acid) Injection is amino acids used in conjunction with other measures, to provide nutritional support for uremic patients, particularly when oral nutrition is infeasible or impractical. Common side effects include fever, infection at the injection site, blood clots, or abnormal increase in blood volume.
Generally, an adult dose of 250 to 500 mL of 5.4% NephrAmine, containing approximately 1.6 to 3.2 grams of nitrogen (in 13.4 to 26.8 grams of essential amino acids), is given daily. NephrAmine may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, NephrAmine should be given only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our 5.4% NephrAmine (essential amino acid) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Nephramine FDA Prescribing Information: Side Effects
See WARNINGS and Special Precautions for Central Venous Nutrition.
Symptoms may result from an excess or deficit of one or more of the ions present in the solution infused, therefore, frequent monitoring of electrolyte levels is essential.
Infrequent instances of hyperammonemia have been reported following administration of essential amino acid solutions to patients with massive gastrointestinal hemorrhage, nonuremic infants and pediatric patients or following administration of higher than recommended doses to adult or pediatric patients. Elevated plasma amino acid levels (hypermethionemia) have also been reported in infants especially in higher dosage ranges. Elevated serum ammonia levels, plasma amino acid levels, and clinical symptoms may subside when the infusions are discontinued.
Phosphorus deficiency may lead to impaired tissue oxygenation and acute hemolytic anemia. Relative to calcium, excessive phosphorus intake can precipitate hypocalcemia with cramps, tetany, and muscular hyperexcitability.
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
Read the entire FDA prescribing information for Nephramine (Essential Amino Acid Injection) »
Additional Nephramine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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