July 1, 2015
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Nesacaine

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Nesacaine

Nesacaine®
(chloroprocaine HCl) Injection, USP

Nesacaine®-MPF
(chloroprocaine HCl) Injection, USP

For Infiltration and Nerve Block

DRUG DESCRIPTION

Nesacaine (chloroprocaine) and Nesacaine (chloroprocaine) -MPF Injections are sterile non pyrogenic local anesthetics. The active ingredient in Nesacaine and Nesacaine-MPF Injections is chloroprocaine HCl (benzoic acid, 4-amino-2-chloro-2-(diethylamino) ethyl ester, monohydrochloride), which is represented by the following structural formula:

Nesacaine® 
  (chloroprocaine HCl) Structural Formula Illustration

Table 1: Composition of Available Injections

Formula (mg/mL)
Product Identification Chloro-procaine HCl Sodium Chloride Disodium EDTA dihydrate Methylparaben
Nesacaine 1% 10 6.7 0.111 1
Nesacaine 2% 20 4.7 0.111 1
Nesacaine-MPF 2% 20 4.7 - -
Nesacaine-MPF 3% 30 3.3 - -

The solutions are adjusted to pH 2.7–4.0 by means of sodium hydroxide and/or hydrochloric acid. Filled under nitrogen. Nesacaine (chloroprocaine) and Nesacaine (chloroprocaine) -MPF Injections should not be resterilized by autoclaving.

Last reviewed on RxList: 3/9/2010
This monograph has been modified to include the generic and brand name in many instances.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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