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Neulasta

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Neulasta

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OVERDOSE

The maximum amount of Neulasta® (pegfilgrastim) that can be safely administered in single or multiple doses has not been determined. Single subcutaneous doses of 300 mcg/kg have been administered to 8 healthy volunteers and 3 patients with non-small cell lung cancer without serious adverse effects. These patients experienced a mean maximum ANC of 55 x 109/L, with a corresponding mean maximum WBC of 67 x 109/L. The absolute maximum ANC observed was 96 x 109/L with a corresponding absolute maximum WBC observed of 120 x 109/L. The duration of leukocytosis ranged from 6 to 13 days. Leukapheresis should be considered in the management of symptomatic individuals.

CONTRAINDICATIONS

Neulasta® (pegfilgrastim) is contraindicated in patients with known hypersensitivity to pegfilgrastim or Filgrastim.

Last reviewed on RxList: 6/27/2008
This monograph has been modified to include the generic and brand name in many instances.

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