Neumega (Oprelvekin) Drug Information: Overdosage and Contraindications

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May 27, 2012

Neumega

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Cancer is the uncontrolled growth of abnormal cells anywhere in a body. The abnormal cells are termed cancer cells, malignant cells, or tumor cells. Many cancers and the abnormal cells that compose the cancer tissue are further identified by the name of the tissue that the abnormal cells originated from (for example, breast cancer, lung cancer, colon cancer). Cancer is not confined to humans; animals and other living organisms can get cancer. Below is a schematic that shows normal cell division and how when a cell is damaged or altered without repair to its system, the cell usually dies. Also shown is what can occur when such damaged or unrepaired cells do not die and become cancer cells and proliferate with uncontrolled growth; a mass of cancer cells develop. Frequently, cancer cells can break away from this original mass of cells, travel through the blood and lymph systems, and lodge in other organs where they can again repeat the ...

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OVERDOSE

Doses of Neumega (oprelvekin) above 125 µg/kg have not been administered to humans. While clinicalexperience is limited, doses of Neumega (oprelvekin) greater than 50 µg/kg may be associated with anincreased incidence of cardiovascular events in adult patients (see WARNINGS, Fluid Retention and Cardiovascular Events). If an overdose of Neumega (oprelvekin) is administered, Neumega (oprelvekin) should be discontinued, and the patient should be closely observed for signs of toxicity (see WARNINGS and ADVERSE REACTIONS). Reinstitution of Neumega (oprelvekin) therapy should be based upon individual patient factors (eg, evidence of toxicity, continued need for therapy).

CONTRAINDICATIONS

Neumega (oprelvekin) is contraindicated in patients with a history of hypersensitivity to Neumega (oprelvekin) or any component of the product (see WARNINGS, Allergic Reactions Including Anaphylaxis).

Last reviewed on RxList: 10/21/2008
This monograph has been modified to include the generic and brand name in many instances.