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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

(rotigotine transdermal system)



Neupro is a transdermal system that provides continuous delivery of rotigotine, a non-ergoline dopamine agonist, for 24 hours following application to intact skin.

Neupro is available in six strengths as shown in Table 4.

Table 4 : Nominal Dose, Drug Content, and Transdermal System Size

Neupro Nominal Dose Rotigotine Content per System Neupro System Size
1 mg/24 hours 2.25 mg 5 cm²
2 mg/24 hours 4.5 mg 10 cm²
3 mg/24 hours 6.75 mg 15 cm²
4 mg/24 hours 9 mg 20 cm²
6 mg/24 hours 13.5 mg 30 cm²
8 mg/24 hours 18 mg 40 cm²

The chemical name of rotigotine is (6S)-6-{propyl[2-(2-thienyl)ethyl]amino}-5,6,7,8-tetrahydro-1-naphthalenol. The empirical formula is C19H25NOS. The molecular weight is 315.48. The structural formula for rotigotine is:.

Neupro (Rotigotine) Structural Formula Illustration

System Components and Structure

Neupro is a thin, matrix-type transdermal system composed of three layers as shown in Figure 1:

Figure 1: System Schematic

System Schematic - Illustration

A flexible, tan-colored backing film, consisting of an aluminized polyester film coated with a pigment-layer on the outer side. The backing provides structural support and protection of the drug-loaded adhesive layer from the environment.

A self-adhesive drug matrix layer, consisting of the active component rotigotine and the following inactive components: ascorbyl palmitate, povidone, silicone adhesive, sodium metabisulfite, and dl-alpha-tocopherol.

A protective liner, consisting of a transparent fluoropolymer-coated polyester film. This liner protects the adhesive layer during storage and is removed just prior to application.

Last reviewed on RxList: 4/13/2012
This monograph has been modified to include the generic and brand name in many instances.


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