May 25, 2017
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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

(rotigotine) Transdermal System


Neupro is a transdermal system that provides continuous delivery of rotigotine, a non-ergoline dopamine agonist, for 24 hours following application to intact skin.

Neupro is available in six strengths as shown in Table 4.

Table 4 : Nominal Dose, Drug Content, and Transdermal System Size

Neupro Nominal Dose Rotigotine Content per System Neupro System Size
1 mg/24 hours 2.25 mg 5 cm²
2 mg/24 hours 4.5 mg 10 cm²
3 mg/24 hours 6.75 mg 15 cm²
4 mg/24 hours 9 mg 20 cm²
6 mg/24 hours 13.5 mg 30 cm²
8 mg/24 hours 18 mg 40 cm²

The chemical name of rotigotine is (6S)-6-{propyl[2-(2-thienyl)ethyl]amino}-5,6,7,8-tetrahydro-1-naphthalenol. The empirical formula is C19H25NOS. The molecular weight is 315.48. The structural formula for rotigotine is:.

Neupro (Rotigotine) Structural Formula Illustration

System Components and Structure

Neupro is a thin, matrix-type transdermal system composed of three layers as shown in Figure 1:

Figure 1: System Schematic

System Schematic - Illustration

A flexible, tan-colored backing film, consisting of an aluminized polyester film coated with a pigment-layer on the outer side. The backing provides structural support and protection of the drug-loaded adhesive layer from the environment.

A self-adhesive drug matrix layer, consisting of the active component rotigotine and the following inactive components: ascorbyl palmitate, povidone, silicone adhesive, sodium metabisulfite, and dl-alpha-tocopherol.

A protective liner, consisting of a transparent fluoropolymer-coated polyester film. This liner protects the adhesive layer during storage and is removed just prior to application.

What are the precautions when taking rotigotine transdermal system (Neupro)?

Before using rotigotine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, sleep disorders (such as sleep apnea, narcolepsy), low/high blood pressure, heart disease (such as heart failure), kidney disease, mental/mood disorders (such as schizophrenia).

This medication may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. See also Side...

Read All Potential Precautions of Neupro »

Last reviewed on RxList: 2/14/2017
This monograph has been modified to include the generic and brand name in many instances.

Neupro - User Reviews

Neupro User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Neupro sorted by most helpful. Patient Discussions FAQs

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