Neupro
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Neupro
Please Note: This Brand Name drug is no longer available in the US.(Generic versions may still be available.)
Neupro
(rotigotine transdermal system)
DRUG DESCRIPTION
Neupro is a transdermal system that provides continuous delivery of rotigotine, a non-ergoline dopamine agonist, for 24 hours following application to intact skin.
Neupro is available in six strengths as shown in Table 4.
Table 4 : Nominal Dose, Drug Content, and Transdermal
System Size
| Neupro Nominal Dose | Rotigotine Content per System | Neupro System Size |
| 1 mg/24 hours | 2.25 mg | 5 cm² |
| 2 mg/24 hours | 4.5 mg | 10 cm² |
| 3 mg/24 hours | 6.75 mg | 15 cm² |
| 4 mg/24 hours | 9 mg | 20 cm² |
| 6 mg/24 hours | 13.5 mg | 30 cm² |
| 8 mg/24 hours | 18 mg | 40 cm² |
The chemical name of rotigotine is (6S)-6-{propyl[2-(2-thienyl)ethyl]amino}-5,6,7,8-tetrahydro-1-naphthalenol. The empirical formula is C19H25NOS. The molecular weight is 315.48. The structural formula for rotigotine is:.
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System Components and Structure
Neupro is a thin, matrix-type transdermal system composed of three layers as shown in Figure 1:
Figure 1: System Schematic
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A flexible, tan-colored backing film, consisting of an aluminized polyester film coated with a pigment-layer on the outer side. The backing provides structural support and protection of the drug-loaded adhesive layer from the environment.
A self-adhesive drug matrix layer, consisting of the active component rotigotine and the following inactive components: ascorbyl palmitate, povidone, silicone adhesive, sodium metabisulfite, and dl-alpha-tocopherol.
A protective liner, consisting of a transparent fluoropolymer-coated polyester film. This liner protects the adhesive layer during storage and is removed just prior to application.
Last reviewed on RxList: 4/13/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Neupro Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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