Neupro
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Neupro
Please Note: This Brand Name drug is no longer available in the US.(Generic versions may still be available.)
Neupro
(rotigotine transdermal system)
DRUG DESCRIPTION
Neupro is a transdermal system that provides continuous delivery of rotigotine, a non-ergoline dopamine agonist, for 24 hours following application to intact skin.
Neupro is available in six strengths as shown in Table 4.
Table 4 : Nominal Dose, Drug Content, and Transdermal
System Size
| Neupro Nominal Dose | Rotigotine Content per System | Neupro System Size |
| 1 mg/24 hours | 2.25 mg | 5 cm² |
| 2 mg/24 hours | 4.5 mg | 10 cm² |
| 3 mg/24 hours | 6.75 mg | 15 cm² |
| 4 mg/24 hours | 9 mg | 20 cm² |
| 6 mg/24 hours | 13.5 mg | 30 cm² |
| 8 mg/24 hours | 18 mg | 40 cm² |
The chemical name of rotigotine is (6S)-6-{propyl[2-(2-thienyl)ethyl]amino}-5,6,7,8-tetrahydro-1-naphthalenol. The empirical formula is C19H25NOS. The molecular weight is 315.48. The structural formula for rotigotine is:.
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System Components and Structure
Neupro is a thin, matrix-type transdermal system composed of three layers as shown in Figure 1:
Figure 1: System Schematic
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A flexible, tan-colored backing film, consisting of an aluminized polyester film coated with a pigment-layer on the outer side. The backing provides structural support and protection of the drug-loaded adhesive layer from the environment.
A self-adhesive drug matrix layer, consisting of the active component rotigotine and the following inactive components: ascorbyl palmitate, povidone, silicone adhesive, sodium metabisulfite, and dl-alpha-tocopherol.
A protective liner, consisting of a transparent fluoropolymer-coated polyester film. This liner protects the adhesive layer during storage and is removed just prior to application.
Last reviewed on RxList: 4/13/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Neupro Information
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