Recommended Topic Related To:

Neutrexin

"Oct. 23, 2012 -- Wider use of colonoscopy has led to a more dramatic decline in colorectal cancer rates, a new study suggests.

Colorectal cancer cases and deaths have been falling for decades, with the most recent decline likely due t"...

Neutrexin

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Neutrexin

OVERDOSE

Neutrexin (trimetrexate glucuronate for injection) administered without concurrent leucovorin can cause lethal complications. There has been no extensive experience in humans receiving single intravenous doses of trimetrexate greater than 90 mg/m2/day with concurrent leucovorin. The toxicities seen at this dose were primarily hematologic. In the event of overdose, Neutrexin (trimetrexate glucuronate inj) should be stopped and leucovorin should be administered at a dose of 40 mg/m2 every 6 hours for 3 days. The LD50 of intravenous trimetrexate in mice is 62 mg/kg (186 mg/m2).

CONTRAINDICATIONS

Neutrexin (trimetrexate glucuronate for injection) is contraindicated in patients with clinically significant sensitivity to trimetrexate, leucovorin, or methotrexate.

Last reviewed on RxList: 4/20/2009
This monograph has been modified to include the generic and brand name in many instances.

A A A

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Cancer

Get the latest treatment options.

Related Drugs
Health Resources
advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations