"Patients with advanced colorectal cancer who are no longer responding to other therapies will now have another option, a new oral medication.
The new product, a combination of trifluridine and tipiracil (Lonsurf, Taiho Pharmace"...
(Generic versions may still be available.)
Neutrexin (trimetrexate glucuronate for injection) administered without concurrent leucovorin can cause lethal complications. There has been no extensive experience in humans receiving single intravenous doses of trimetrexate greater than 90 mg/m2/day with concurrent leucovorin. The toxicities seen at this dose were primarily hematologic. In the event of overdose, Neutrexin (trimetrexate glucuronate inj) should be stopped and leucovorin should be administered at a dose of 40 mg/m2 every 6 hours for 3 days. The LD50 of intravenous trimetrexate in mice is 62 mg/kg (186 mg/m2).
Last reviewed on RxList: 4/20/2009
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