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In this Article

• What is sorafenib (Nexavar)?
• What are the possible side effects of sorafenib (Nexavar)?
• What is the most important information I should know about sorafenib (Nexavar)?
• What should I discuss with my health care provider before taking sorafenib (Nexavar)?
• How should I take sorafenib (Nexavar)?
• What happens if I miss a dose (Nexavar)?
• What happens if I overdose (Nexavar)?
• What should I avoid while taking sorafenib (Nexavar)?
• What other drugs will affect sorafenib (Nexavar)?
• Where can I get more information?

What happens if I miss a dose (Nexavar)?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Nexavar)?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include severe diarrhea, and skin rash, redness, swelling, or blistering.

What should I avoid while taking sorafenib (Nexavar)?

Use birth control to prevent pregnancy while you are using sorafenib, whether you are a man or a woman. Continue using birth control for at least 2 weeks after you stop taking sorafenib.

What other drugs will affect sorafenib (Nexavar)?

Before taking sorafenib, tell your doctor if you are using any of the following drugs:

• the blood thinner warfarin (Coumadin);
• dexamethasone (Decadron, Hexadrol);
• rifampin (Rifadin, Rifater, Rifamate, Rimactane);
• St. John's wort;
• seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal, Solfoton); or
• other cancer medications such as docetaxel (Taxotere), doxorubicin (Adriamycin, Rubex) or irinotecan (Camptosar).

This list is not complete and there may be other drugs that can interact with sorafenib. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about sorafenib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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