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(amiodaronc HC1) Injection for intravenous use


NEXTERONE contains amiodarone HCl (C25H29I2NO3•HCl), a class III antiarrhythmic drug. Amiodarone HC1 is (2-butyl-3-benzo-furanyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanonehydrochloride.

Amiodarone HC1 has the following structural formula:

  (amiodaronc HC1) Structural Formula Illustration

Amiodarone HC1 is a white to slightly yellow crystalline powder, and is very slightly soluble in water. It has a molecular weight of 681.78 and contains 37.3% iodine by weight. NEXTERONE is a sterile clear, colorless to slightly yellow solution visually free from particulates. Each mL of NEXTERONE contains 50 mg of amiodarone HC1,225 mg sulfobutylether beta-cyclodextrin sodium, 3.8 mg citric acid monohydrate, 2.1 mg sodium citrate dihydrate and water for injection. Sodium hydroxide or citric acid monohydrate may have been added to adjust pH. NEXTERONE does not contain polysorbate 80 or benzyl alcohol.

What are the possible side effects of amiodarone injection (Nexterone)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

You may continue to have side effects from amiodarone after you stop using it. It could take up to several months for the medicine to completely clear from your body.

Call your doctor at once if you have any of these serious side effects, even if they occur up to several months after you stop using amiodarone:

  • a new or a worsening irregular heartbeat pattern;
  • fast, slow, or pounding...

Read All Potential Side Effects and See Pictures of Nexterone »

Last reviewed on RxList: 1/6/2012
This monograph has been modified to include the generic and brand name in many instances.


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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