Niacin And Niacinamide (Vitamin B3)
- What other names is Niacin And Niacinamide (vitamin B3) known by?
- What is Niacin And Niacinamide (vitamin B3)?
- How does Niacin And Niacinamide (vitamin B3) work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Niacin And Niacinamide (vitamin B3).
Niacin is used for high cholesterol. It is also used along with other treatments for circulation problems, migraine headache, dizziness, and to reduce the diarrhea associated with cholera. Niacin is also used for preventing positive urine drug screens in people who take illegal drugs.
Niacinamide is used for treating diabetes and two skin conditions called bullous pemphigoid and granuloma annulare.
Niacin or niacinamide is used for preventing vitamin B3 deficiency and related conditions such as pellagra. Each of these forms of vitamin B3 is used for schizophrenia, hallucinations due to drugs, Alzheimer's disease and age-related loss of thinking skills, chronic brain syndrome, depression, motion sickness, alcohol dependence, and fluid collection (edema).
Some people use niacin or niacinamide for acne, leprosy, attention deficit-hyperactivity disorder (ADHD), memory loss, arthritis, preventing premenstrual headache, improving digestion, protecting against toxins and pollutants, reducing the effects of aging, lowering blood pressure, improving circulation, promoting relaxation, improving orgasm, and preventing cataracts.
Niacinamide is applied to the skin for treating a skin condition called inflammatory acne vulgaris.
Likely Effective for...
- High cholesterol. Only niacin seems to lower cholesterol, not niacinamide. Some niacin products are FDA-approved prescription products for treating high cholesterol. These prescription niacin products typically come in high strengths of 500 mg or higher. Dietary supplement forms of niacin usually come in strengths of 250 mg or less. Since very high doses of niacin are required for high cholesterol, dietary supplement niacin usually isn't appropriate.
- Treatment and prevention of niacin deficiency, and certain conditions related to niacin deficiency such as pellagra. Both niacin and niacinamide are approved by the U.S. Food and Drug Administration (FDA) for these uses. Niacinamide is sometimes preferred because it doesn't cause "flushing," (redness, itching and tingling), a side effect of niacin treatment.
Possibly Effective for...
- Osteoarthritis. Taking niacinamide seems to improve joint flexibility and reduce pain and swelling. Some people who take niacinamide might be able to cut down on standard painkilling medications.
- Alzheimer's disease. People who consume higher amounts of niacin from food and multivitamin sources seem to have a lower risk of getting Alzheimer's disease than people who consume less niacin. But there is no evidence that taking a stand-alone niacin supplement helps to prevent Alzheimer's disease.
- Hardening of the arteries (atherosclerosis).
- Reducing the risk of a second heart attack in men with heart or circulatory disorders.
- Diarrhea from an infection called cholera.
- Diabetes, types 1 and 2.
- Prevention and treatment of cataracts, an eye condition.
Insufficient Evidence to Rate Effectiveness for...
- Attention deficit-hyperactivity disorder (ADHD). There is conflicting evidence regarding the usefulness of niacinamide in combination with other vitamins for the treatment of ADHD.
- Migraine headache.
- Motion sickness.
- Alcohol dependence.
- Improving orgasm.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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