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NICOTROL® Inhaler (nicotine inhalation system) consists of a mouthpiece and a plastic cartridge delivering 4 mg of nicotine from a porous plug containing 10 mg nicotine. The cartridge is inserted into the mouthpiece prior to use. Nicotine is a tertiary amine composed of a pyridine and a pyrrolidine ring. It is a colorless to pale yellow, freely water-soluble, strongly alkaline, oily, volatile, hygroscopic liquid obtained from the tobacco plant. Nicotine has a characteristic pungent odor and turns brown on exposure to air or light. Of its two stereoisomers, S(-)nicotine is the more active. It is the prevalent form in tobacco, and is the form in the NICOTROL (nicotine inhalation system) Inhaler. The free alkaloid is absorbed rapidly through skin, mucous membranes, and the respiratory tract.
Chemical Name: S-3-(1-methyl-2-pyrrolidinyl) pyridine
Molecular Formula: C10H14N2
Molecular Weight: 162.23
Ionization Constants: pKa1 = 7.84, pKa2 = 3.04 at 15°C
Octanol-Water Partition Coefficient: 15:1 at pH 7
Nicotine is the active ingredient; inactive components of the product are menthol and a porous plug which are pharmacologically inactive. Nicotine is released when air is inhaled through the Inhaler.
What are the possible side effects of nicotine gum or lozenges?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have a serious side effect such as:
- blisters inside your mouth;
- fast or pounding heartbeats, fluttering in your chest;
- extreme weakness or dizziness;
- severe nausea and vomiting; or
- bronchospasm (wheezing, tightness in your chest, trouble breathing).
Less serious side effects may include:
What are the precautions when taking nicotine inhalation system (Nicotrol)?
Before using this product, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as menthol), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: uncontrolled/worsening chest pain, recent heart attack, irregular heartbeat (serious arrhythmias).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood vessel disease (e.g., Raynaud's disease, stroke), breathing problems (e.g., asthma, emphysema), diabetes, heart disease (e.g., chest pain, heart...
Last reviewed on RxList: 3/18/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Nicotrol Information
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