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NILANDRON® tablets contain nilutamide, a nonsteroidal, orally active antiandrogen having the chemical name 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione with the following structural formula:
Nilutamide is a microcrystalline, white to practically white powder with a molecular weight of 317.25.
Its molecular formula is C12H10F3N3O4.
It is freely soluble in ethyl acetate, acetone, chloroform, ethyl alcohol, dichloromethane, and methanol. It is slightly soluble in water [ < 0.1% W/V at 25°C (77°F)]. It melts between 153°C and 156°C (307.4°F and 312.8°F).
Each NILANDRON tablet contains 150 mg of nilutamide. Other ingredients in NILANDRON (nilutamide) tablets are corn starch, lactose, povidone, docusate sodium, magnesium stearate, and talc.
What are the possible side effects of nilutamide (Nilandron)?
If you experience any of the following serious side effects, stop taking nilutamide, and seek emergency medical attention or notify your doctor immediately:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives),
- shortness of breath, cough, chest pain, or fever;
- liver damage (yellow skin or eyes, dark urine, itching, persistent appetite loss, pain in the upper right stomach area, or unexplained flulike symptoms).
Other less serious side effects may be more likely to occur. Continue to take...
What are the precautions when taking nilutamide (Nilandron)?
Before taking nilutamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (such as asthma, chronic obstructive pulmonary disease-COPD, emphysema), liver problems.
This drug may rarely make you dizzy, drowsy, or cause vision changes. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. You may also develop intolerance to alcohol while taking this medication. Avoid alcoholic beverages...
Last reviewed on RxList: 10/14/2008
This monograph has been modified to include the generic and brand name in many instances.
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