Nimotop (Nimodipine) Drug Information: Overdosage and Contraindications

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May 27, 2012

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Calcium Channel Blockers (CCBs) »

What are calcium channel blockers (CCBs) and how do they work?

Calcium channel blockers are drugs that block the entry of calcium into the muscle cells of the heart and arteries.

The entry of calcium is critical for the conduction of the electrical signal that passes from muscle cell to muscle cell of the heart, and signals the cells to contract.
It also is necessary in order for the muscle cells to contract and thereby pump blood.
In the arteries, the entry of calcium into muscle cells causes contraction of the cells and thereby dilates (widens) the arteries.
Thus, by blocking the entry of calcium, calcium channel blockers reduce electrical conduction within the heart, decrease the force of contraction (work) of the muscle cells, and dilate arteries.
Dilation of the arteries reduces blood pressure and thereby the effort the heart must exert to pump blood.
Combined with decr...

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OVERDOSE

There have been no reports of overdosage from the oral administration of Nimotop® (nimodipine) . Symptoms of overdosage would be expected to be related to cardiovascular effects such as excessive peripheral vasodilation with marked systemic hypotension. Clinically significant hypotension due to Nimotop® (nimodipine) overdosage may require active cardiovascular support with pressor agents. Specific treatments for calcium channel blocker overdose should also be given promptly. Since Nimotop® (nimodipine) is highly protein-bound, dialysis is not likely to be of benefit.