"SYDNEY, AUSTRALIA â€” A small randomized trial reports sharp blood-pressure reductions in untreated hypertensives using a single pill combining four BP-lowering drugs at one-quarter the usual dose.
Among 18 patients, mean 24-hour systol"...
(sodium nitroprusside) Injection
(A) EXCESSIVE HYPOTENSION; (B) CYANIDE TOXICITY
(A) Excessive Hypotension
Sodium Nitroprusside can cause precipitous decreases in blood pressure which can lead to irreversible ischemic injuries or death. Use only with continuous blood pressure monitoring [see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS].
(B) Cyanide Toxicity
Sodium nitroprusside metabolism produces dose-related cyanide, which can be lethal. A patient’s ability to buffer cyanide will be exceeded in less than one hour at the maximum dose rate (10 mcg/kg/min); limit infusions at the maximum rate to as short a duration as possible [see WARNINGS AND PRECAUTIONS].
Sodium nitroprusside is disodium pentacyanonitrosylferrate(2-) dihydrate, a hypotensive agent whose structural formula is
Sodium Nitroprusside has molecular formula Na2[Fe(CN)5NO] • 2H2O and molecular weight of 297.95. Dry sodium nitroprusside is a reddish-brown powder, soluble in water.
Sodium nitroprusside solution is rapidly degraded by trace contaminants, often with resulting color changes [see DOSAGE AND ADMINISTRATION].
NIPRIDE RTU is supplied as a sterile, unpreserved, colorless to red-brown solution packaged in a single-use 100-mL vial. Each 100 mL of solution in vial contains 50 mg of sodium nitroprusside (0.5 mg/mL), 900 mg of sodium chloride, USP (9 mg/mL), in sterile water for injection, USP.
Last reviewed on RxList: 3/16/2017
This monograph has been modified to include the generic and brand name in many instances.
Additional Nipride RTU Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.