May 27, 2017
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Nipride RTU

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Nipride RTU

(sodium nitroprusside) Injection



(A) Excessive Hypotension

Sodium Nitroprusside can cause precipitous decreases in blood pressure which can lead to irreversible ischemic injuries or death. Use only with continuous blood pressure monitoring [see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS].

(B) Cyanide Toxicity

Sodium nitroprusside metabolism produces dose-related cyanide, which can be lethal. A patient’s ability to buffer cyanide will be exceeded in less than one hour at the maximum dose rate (10 mcg/kg/min); limit infusions at the maximum rate to as short a duration as possible [see WARNINGS AND PRECAUTIONS].


Sodium nitroprusside is disodium pentacyanonitrosylferrate(2-) dihydrate, a hypotensive agent whose structural formula is

NIPRIDE RTU (sodium nitroprusside) Structural Formula Illustration

Sodium Nitroprusside

Sodium Nitroprusside has molecular formula Na2[Fe(CN)5NO] • 2H2O and molecular weight of 297.95. Dry sodium nitroprusside is a reddish-brown powder, soluble in water.

Sodium nitroprusside solution is rapidly degraded by trace contaminants, often with resulting color changes [see DOSAGE AND ADMINISTRATION].

NIPRIDE RTU is supplied as a sterile, unpreserved, colorless to red-brown solution packaged in a single-use 100-mL vial. Each 100 mL of solution in vial contains 50 mg of sodium nitroprusside (0.5 mg/mL), 900 mg of sodium chloride, USP (9 mg/mL), in sterile water for injection, USP.

Last reviewed on RxList: 3/16/2017
This monograph has been modified to include the generic and brand name in many instances.

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