February 5, 2016
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Nitrolingual Pumpspray

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Nitrolingual Pumpspray

Nitrolingual Pumpspray Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 12/19/2015

Nitrolingual Pumpspray (nitroglycerin lingual spray) is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump, used to treat or prevent attacks of chest pain (angina). Common side effects of Nitrolingual Pumpspray include mild burning or tingling with the tablet in the mouth, warmth, redness, or tingly feeling under the skin, or feeling weak or dizzy. Contact your doctor if you have signs of a severe allergic reaction after using Nitrolingual Pumpspray, including hives, difficulty breathing, swelling of your face/lips/tongue/throat, rash or itching, tightness in the chest, blurred vision, irregular heart rate, pale skin, feeling like you might pass out, or fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

The recommended dose of Nitrolingual Pumpspray is at the onset of an attack to administer one or two metered sprays onto or under the tongue. No more than three metered sprays are recommended within a 15-minute period. Nitrolingual Pumpspray may interact with alteplase, aspirin, heparin, bladder or urinary medications, blood pressure medications, bronchodilators, dihydroergotamine, ergotamine, erectile dysfunction medications, antidepressants, beta-blockers, calcium channel blockers, irritable bowel medications, medications that cause dry mouth, or medicines to treat psychiatric disorders. Many other drugs can interact with Nitrolingual Pumpspray. Tell your doctor all medications and supplements you use. During pregnancy, Nitrolingual Pumpspray should be taken only if prescribed. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Nitrolingual Pumpspray (nitroglycerin lingual spray) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Nitrolingual Pumpspray in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast, slow, pounding, or uneven heart rate;
  • blurred vision or dry mouth;
  • nausea, vomiting, sweating, pale skin, feeling like you might pass out; or
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may include:

  • mild burning or tingling with the tablet in your mouth;
  • warmth, redness, or tingly feeling under your skin; or
  • feeling weak or dizzy.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Nitrolingual Pumpspray (Nitroglycerin Lingual Spray)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Nitrolingual Pumpspray FDA Prescribing Information: Side Effects
(Adverse Reactions)


Adverse reactions to oral nitroglycerin dosage forms, particularly headache and hypotension, are generally dose-related. In clinical trials at various doses of nitroglycerin, the following adverse effects have been observed: Headache, which may be severe and persistent, is the most commonly reported side effect of nitroglycerin with an incidence on the order of about 50% in some studies. Cutaneous vasodilation with flushing may occur. Transient episodes of dizziness and weakness, as well as other signs of cerebral ischemia associated with postural hypotension, may occasionally develop. Occasionally, an individual may exhibit marked sensitivity to the hypotensive effects of nitrates and severe responses (nausea, vomiting, weakness, restlessness, pallor, perspiration and collapse) may occur even with therapeutic doses. Drug rash and/or exfoliative dermatitis have been reported in patients receiving nitrate therapy. Nausea and vomiting appear to be uncommon.

Nitrolingual® Pumpspray (nitroglycerin lingual spray) given to 51 chronic stable angina patients in single doses of 0.4, 0.8 and 1.6 mg as part of a double-blind, 5-period single-dose cross-over study exhibited an adverse event profile that was generally mild to moderate. Adverse events occurring at a frequency greater than 2% included: headache, dizziness, and paresthesia. Less frequently reported events in this trial included ( < 2%): dyspnea, pharyngitis, rhinitis, vasodilation, peripheral edema, asthenia, and abdominal pain.

Read the entire FDA prescribing information for Nitrolingual Pumpspray (Nitroglycerin Lingual Spray)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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