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Patient Counseling Information

Interaction with PDE5 inhibitors

NitroMist (nitroglycerin lingual aerosol) should not be used in patients who are using medications for erectile dysfunction such as sildenafil, vardenafil, and tadalafil. These products have been shown to increase the hypotensive effects of nitrate drug such as NitroMist (nitroglycerin lingual aerosol) .


NitroMist (nitroglycerin lingual aerosol) is meant to be sprayed on or under the tongue at the beginning of angina or to prevent an angina attack. Treatment with nitroglycerin products such as NitroMist (nitroglycerin lingual aerosol) may be associated with lightheadedness on standing, especially just after rising from a laying or seated position. This effect may be more frequent in patients who have consumed alcohol, since alcohol use contributes to hypotension. If possible, patients should be seated when taking NitroMist (nitroglycerin lingual aerosol) . This reduces the likelihood of falling due to lightheadedness or dizziness [see DOSAGE AND ADMINISTRATION ].


Headaches can sometimes accompany treatment with nitroglycerin. In patients who get these headaches, the headaches may indicate activity of the drug. Tolerance to headaches develops.


Flushing, drug rash and exfoliative dermatitis have been reported in patients receiving nitrate therapy.

Container information

The NitroMist (nitroglycerin lingual aerosol) bottle should not be forcefully opened. Because NitroMist (nitroglycerin lingual aerosol) contains a highly flammable propellant (butane), do not have the container burned after use and do not spray directly towards flames,

While the container is in the upright position, if the liquid reaches the top to middle of the hole on the side of the container, a new supply should be obtained. When the liquid reaches the bottom of the hole, the remaining doses will have less than label content.

Last reviewed on RxList: 3/26/2007
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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