"The U.S. Food and Drug Administration today approved Impavido (miltefosine) to treat a tropical disease called leishmaniasis.
Leishmaniasis is a disease caused by Leishmania, a parasite which is transmitted to humans through sand fly bites."...
In the event of acute accidental overdose, treatment consists of supportive and symptomatic measures. Within the first hour after ingestion, activated charcoal may be administered.
Coadministration of a number of CYP3A4 substrates is contraindicated with NIZORAL® Tablets. Coadministration with ketoconazole can cause elevated plasma concentrations of these drugs and may increase or prolong both therapeutic and adverse effects. For example, increased plasma concentrations of some of these drugs can lead to QT prolongation and ventricular tachyarrhythmias including occurrences of torsades de pointes, a potentially fatal arrhythmia. See WARNINGS section, and PRECAUTIONS: DRUG INTERACTIONS section for specific examples.
The use of NIZORAL® Tablets is contraindicated in patients with acute or chronic liver disease.
NIZORAL® is contraindicated in patients who have shown hypersensitivity to the drug.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 8/2/2013
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