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Nizoral Shampoo

Last reviewed on RxList: 2/13/2017
Nizoral Shampoo Side Effects Center

Last reviewed on RxList 9/14/2016

Nizoral (ketoconazole) 2% Shampoo is an antifungal medication used to treat fungal infections of the skin such as athlete's foot, jock itch, ringworm, and seborrhea (dry, flaking skin). Nizoral is available as a cream, gel, and shampoo. Nizoral shampoo is used for the treatment of dandruff. Nizoral shampoo is available in generic form and over-the-counter. Common side effects of Nizoral shampoo include:

  • mild skin itching or irritation,
  • dry skin,
  • abnormal hair texture,
  • scalp pustules,
  • oiliness and dryness of hair and scalp,
  • rash,
  • hives,
  • application site reactions, or
  • headache.

Apply the shampoo to the damp skin of the affected area and a wide margin surrounding this area. Lather, leave in place for 5 minutes, and then rinse off with water. One application dose of the shampoo should be sufficient. Nizoral may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Nizoral should be used only if prescribed. It may be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Nizoral (ketoconazole) 2% Shampoo Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Nizoral Shampoo Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using ketoconazole topical and call your doctor at once if you have a serious side effect such as:

  • severe itching, burning, or irritation where the medicine is applied;
  • oily or dry scalp, mild hair loss;
  • redness, pain, or oozing of treated skin areas; or
  • eye redness, swelling, or irritation.

Less serious side effects include:

  • mild skin itching or irritation;
  • dry skin; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Nizoral Shampoo (Ketoconazole 2%)

Nizoral Shampoo Professional Information

SIDE EFFECTS

Clinical Trials Experience

In 11 double-blind trials in 264 patients using ketoconazole 2% shampoo for the treatment of dandruff or seborrheic dermatitis, an increase in normal hair loss and irritation occurred in less than 1% of patients. In three open-label safety trials in which 41 patients shampooed 4-10 times weekly for six months, the following adverse experiences each occurred once: abnormal hair texture, scalp pustules, mild dryness of the skin, and itching. As with other shampoos, oiliness and dryness of hair and scalp have been reported. In a double-blind, placebo-controlled trial in which patients with tinea versicolor were treated with either a single application of NIZORAL® (ketoconazole) 2% Shampoo (n=106), a daily application for three consecutive days (n=107), or placebo (n=105), drug-related adverse events occurred in 5 (5%), 7 (7%) and 4 (4%) of patients, respectively. The only events that occurred in more than one patient in any one of the three treatment groups were pruritus, application site reaction, and dry skin; none of these events occurred in more than 3% of the patients in any one of the three groups.

Post-marketing Experience

Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency. The following adverse drug reactions have been identified during post-marketing experience with NIZORAL® (ketoconazole) Shampoo: there have been reports of hair discoloration and abnormal hair texture, itching, skin burning sensation, contact dermatitis, hypersensitivity, angioedema, alopecia, rash, urticaria, skin irritation, dry skin, and application site reactions.

Read the entire FDA prescribing information for Nizoral Shampoo (Ketoconazole 2%)

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© Nizoral Shampoo Patient Information is supplied by Cerner Multum, Inc. and Nizoral Shampoo Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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