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Nolvadex

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Nolvadex

CLINICAL PHARMACOLOGY

NOLVADEX (tamoxifen citrate) is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, tamoxifen appears to exert its antitumor effects by binding the estrogen receptors.

In cytosols derived from human breast adenocarcinomas, tamoxifen competes with estradiol for estrogen receptor protein.

Absorption and Distribution

Following a single oral dose of 20 mg tamoxifen, an average peak plasma concentration of 40 ng/mL (range 35 to 45 ng/mL) occurred approximately 5 hours after dosing. The decline in plasma concentrations of tamoxifen is biphasic with a terminal elimination half-life of about 5 to 7 days. The average peak plasma concentration of N-desmethyl tamoxifen is 15 ng/mL (range 10 to 20 ng/mL). Chronic administration of 10 mg tamoxifen given twice daily for 3 months to patients results in average steady-state plasma concentrations of 120 ng/mL (range 67-183 ng/mL) for tamoxifen and 336 ng/mL (range 148-654 ng/mL) for N-desmethyl tamoxifen. The average steady-state plasma concentrations of tamoxifen and N-desmethyl tamoxifen after administration of 20 mg tamoxifen once daily for 3 months are 122 ng/mL (range 71-183 ng/mL) and 353 ng/mL (range 152-706 ng/mL), respectively. After initiation of therapy, steady state concentrations for tamoxifen are achieved in about 4 weeks and steady-state concentrations for N-desmethyl tamoxifen are achieved in about 8 weeks, suggesting a half-life of approximately 14 days for this metabolite. In a steady-state, crossover study of 10 mg NOLVADEX (tamoxifen citrate) tablets given twice a day vs. a 20 mg NOLVADEX (tamoxifen citrate) tablet given once daily, the 20 mg NOLVADEX (tamoxifen citrate) tablet was bioequivalent to the 10 mg NOLVADEX (tamoxifen citrate) tablets.

Metabolism

Tamoxifen is extensively metabolized after oral administration. N-desmethyl tamoxifen is the major metabolite found in patients' plasma. The biological activity of N-desmethyl tamoxifen appears to be similar to that of tamoxifen. 4-Hydroxytamoxifen and a side chain primary alcohol derivative of tamoxifen have been identified as minor metabolites in plasma. Tamoxifen is a substrate of cytochrome P-450 3A, 2C9 and 2D6, and an inhibitor of P-glycoprotein.

Excretion

Studies in women receiving 20 mg of 14C tamoxifen have shown that approximately 65% of the administered dose was excreted from the body over a period of 2 weeks with fecal excretion as the primary route of elimination. The drug is excreted mainly as polar conjugates, with unchanged drug and unconjugated metabolites accounting for less than 30% of the total fecal radioactivity.

Special Populations

The effects of age, gender and race on the pharmacokinetics of tamoxifen have not been determined. The effects of reduced liver function on the metabolism and pharmacokinetics of tamoxifen have not been determined.

Pediatric Patients

The pharmacokinetics of tamoxifen and N-desmethyl tamoxifen were characterized using a population pharmacokinetic analysis with sparse samples per patient obtained from 27 female pediatric patients aged 2 to 10 years enrolled in a study designed to evaluate the safety, efficacy, and pharmacokinetics of NOLVADEX (tamoxifen citrate) in treating McCune-Albright Syndrome. Rich data from two tamoxifen citrate pharmacokinetic trials in which 59 postmenopausal women with breast cancer completed the studies were included in the analysis to determine the structural pharmacokinetic model for tamoxifen. A one-compartment model provided the best fit to the data.

In pediatric patients, an average steady state peak plasma concentration (Css, max) and AUC were of 187 ng/mL and 4110 ng hr/mL, respectively, and Css, max occurred approximately 8 hours after dosing. Clearance (CL/F) as body weight adjusted in female pediatric patients was approximately 2.3-fold higher than in female breast cancer patients. In the youngest cohort of female pediatric patients (2-6 year olds), CL/F was 2.6-fold higher; in the oldest cohort (7-10.9 year olds) CL/F was approximately 1.9-fold higher. Exposure to N-desmethyl tamoxifen was comparable between the pediatric and adult patients. The safety and efficacy of NOLVADEX (tamoxifen citrate) for girls aged two to 10 years with McCune-Albright Syndrome and precocious puberty have not been studied beyond one year of treatment. The long-term effects of NOLVADEX (tamoxifen citrate) therapy in girls have not been established. In adults treated with NOLVADEX (tamoxifen citrate) an increase in incidence of uterine malignancies, stroke and pulmonary embolism has been noted (see BOXED WARNING).

Drug-Drug Interactions

In vitro studies showed that erythromycin, cyclosporin, nifedipine and diltiazem competitively inhibited formation of N-desmethyl tamoxifen with apparent K1 of 20, 1, 45 and 30 ÁM, respectively. The clinical significance of these in vitro studies is unknown.

Tamoxifen reduced the plasma concentration of letrozole by 37% when these drugs were co-administered. Rifampin, a cytochrome P-450 3A4 inducer reduced tamoxifen AUC and Cmax by 86% and 55%, respectively. Aminoglutethimide reduces tamoxifen and N-desmethyl tamoxifen plasma concentrations. Medroxyprogesterone reduces plasma concentrations of N-desmethyl, but not tamoxifen.

In the anastrozole adjuvant trial, co-administration of anastrozole and NOLVADEX (tamoxifen citrate) in breast cancer patients reduced anastrozole plasma concentration by 27% compared to those achieved with anastrozole alone; however, the coadministration did not affect the pharmacokinetics of tamoxifen or N-desmethyltamoxifen (see PRECAUTIONS -DRUG INTERACTIONS). NOLVADEX (tamoxifen citrate) should not be co-administered with anastrozole.

Clinical Studies

Metastatic Breast Cancer

Premenopausal Women (NOLVADEX (tamoxifen citrate) vs. Ablation)

Three prospective, randomized studies (Ingle, Pritchard, Buchanan) compared NOLVADEX (tamoxifen citrate) to ovarian ablation (oophorectomy or ovarian irradiation) in premenopausal women with advanced breast cancer. Although the objective response rate, time to treatment failure, and survival were similar with both treatments, the limited patient accrual prevented a demonstration of equivalence. In an overview analysis of survival data from the 3 studies, the hazard ratio for death (NOLVADEX (tamoxifen citrate) /ovarian ablation) was 1.00 with two-sided 95% confidence intervals of 0.73 to 1.37. Elevated serum and plasma estrogens have been observed in premenopausal women receiving NOLVADEX (tamoxifen citrate) , but the data from the randomized studies do not suggest an adverse effect of this increase. A limited number of premenopausal patients with disease progression during NOLVADEX (tamoxifen citrate) therapy responded to subsequent ovarian ablation.

Male Breast Cancer

Published results from 122 patients (119 evaluable) and case reports in 16 patients (13 evaluable) treated with NOLVADEX (tamoxifen citrate) have shown that NOLVADEX (tamoxifen citrate) is effective for the palliative treatment of male breast cancer. Sixty-six of these 132 evaluable patients responded to NOLVADEX (tamoxifen citrate) which constitutes a 50% objective response rate.

Adjuvant Breast Cancer

Overview

The Early Breast Cancer Trialists' Collaborative Group (EBCTCG) conducted worldwide overviews of systemic adjuvant therapy for early breast cancer in 1985, 1990, and again in 1995. In 1998, 10-year outcome data were reported for 36,689 women in 55 randomized trials of adjuvant NOLVADEX (tamoxifen citrate) using doses of 20-40 mg/day for 1-5+ years. Twenty-five percent of patients received 1 year or less of trial treatment, 52% received 2 years, and 23% received about 5 years. Forty-eight percent of tumors were estrogen receptor (ER) positive ( > 10 fmol/mg), 21% were ER poor ( < 10 fmol/l), and 31% were ER unknown. Among 29,441 patients with ER positive or unknown breast cancer, 58% were entered into trials comparing NOLVADEX (tamoxifen citrate) to no adjuvant therapy and 42% were entered into trials comparing NOLVADEX (tamoxifen citrate) in combination with chemotherapy vs. the same chemotherapy alone. Among these patients, 54% had node positive disease and 46% had node negative disease.

Among women with ER positive or unknown breast cancer and positive nodes who received about 5 years of treatment, overall survival at 10 years was 61.4% for NOLVADEX (tamoxifen citrate) vs. 50.5% for control (logrank 2p < 0.00001). The recurrence-free rate at 10 years was 59.7% for NOLVADEX (tamoxifen citrate) vs. 44.5% for control (logrank 2p < 0.00001). Among women with ER positive or unknown breast cancer and negative nodes who received about 5 years of treatment, overall survival at 10 years was 78.9% for NOLVADEX (tamoxifen citrate) vs. 73.3% for control (logrank 2p < 0.00001). The recurrence-free rate at 10 years was 79.2% for NOLVADEX (tamoxifen citrate) versus 64.3% for control (logrank 2p < 0.00001).

The effect of the scheduled duration of tamoxifen may be described as follows. In women with ER positive or unknown breast cancer receiving 1 year or less, 2 years or about 5 years of NOLVADEX (tamoxifen citrate) , the proportional reductions in mortality were 12%, 17% and 26%, respectively (trend significant at 2p < 0.003). The corresponding reductions in breast cancer recurrence were 21%, 29% and 47% (trend significant at 2p < 0.00001).

Benefit is less clear for women with ER poor breast cancer in whom the proportional reduction in recurrence was 10% (2p = 0.007) for all durations taken together, or 9% (2p = 0.02) if contralateral breast cancers are excluded. The corresponding reduction in mortality was 6% (NS). The effects of about 5 years of NOLVADEX (tamoxifen citrate) on recurrence and mortality were similar regardless of age and concurrent chemotherapy. There was no indication that doses greater than 20 mg per day were more effective.

Anastrozole Adjuvant ATAC Trial - Study of Anastrozole compared to NOLVADEX (tamoxifen citrate) for Adjuvant Treatment of Early Breast Cancer - An anastrozole adjuvant trial was conducted in 9366 postmenopausal women with operable breast cancer who were randomized to receive adjuvant treatment with either anastrozole 1 mg daily, NOLVADEX (tamoxifen citrate) 20 mg daily, or a combination of these two treatments for five years or until recurrence of the disease. At a median follow-up of 33 months, the combination of anastrozole and NOLVADEX (tamoxifen citrate) did not demonstrate any efficacy benefit when compared with NOLVADEX (tamoxifen citrate) therapy alone in all patients as well as in the hormone receptor-positive subpopulation. This treatment arm was discontinued from the trial. Please refer to CLINICAL PHARMACOLOGY-Special Populations-Drug-Drug Interactions, PRECAUTIONS-Laboratory Tests, PRECAUTIONS-Drug Interactions and ADVERSE REACTIONS sections for safety information from this trial. Please refer to the full prescribing information for ARIMIDEX® (anastrozole) 1 mg Tablets for additional information on this trial.

Patients in the two monotherapy arms of the ATAC trial were treated for a median of 60 months (5 years) and followed for a median of 68 months. Disease-free survival in the intent-to-treat population was statistically significantly improved [Hazard Ratio (HR) = 0.87, 95% CI: 0.78, 0.97, p=0.0127] in the anastrazole arm compared to the NOLVADEX (tamoxifen citrate) arm.

Node Positive - Individual Studies

Two studies (Hubay and NSABP B-09) demonstrated an improved disease-free survival following radical or modified radical mastectomy in postmenopausal women or women 50 years of age or older with surgically curable breast cancer with positive axillary nodes when NOLVADEX (tamoxifen citrate) was added to adjuvant cytotoxic chemotherapy. In the Hubay study, NOLVADEX (tamoxifen citrate) was added to &lequo;low-dose”CMF (cyclophosphamide, methotrexate and fluorouracil). In the NSABP B-09 study, NOLVADEX (tamoxifen citrate) was added to melphalan [L-phenylalanine mustard (P)] and fluorouracil (F).

In the Hubay study, patients with a positive (more than 3 fmol) estrogen receptor were more likely to benefit. In the NSABP B-09 study in women age 50-59 years, only women with both estrogen and progesterone receptor levels 10 fmol or greater clearly benefited, while there was a nonstatistically significant trend toward adverse effect in women with both estrogen and progesterone receptor levels less than 10 fmol. In women age 60-70 years, there was a trend toward a beneficial effect of NOLVADEX (tamoxifen citrate) without any clear relationship to estrogen or progesterone receptor status.

Three prospective studies (ECOG-1178, Toronto, NATO) using NOLVADEX (tamoxifen citrate) adjuvantly as a single agent demonstrated an improved disease-free survival following total mastectomy and axillary dissection for postmenopausal women with positive axillary nodes compared to placebo/no treatment controls. The NATO study also demonstrated an overall survival benefit.

Node Negative - Individual Studies

NSABP B-14, a prospective, double-blind, randomized study, compared NOLVADEX (tamoxifen citrate) to placebo in women with axillary node-negative, estrogen-receptor positive ( ≥ 10 fmol/mg cytosol protein) breast cancer (as adjuvant therapy, following total mastectomy and axillary dissection, or segmental resection<, axillary dissection, and breast radiation). After five years of treatment, there was a significant improvement in disease-free survival in women receiving NOLVADEX (tamoxifen citrate) . This benefit was apparent both in women under age 50 and in women at or beyond age 50.

One additional randomized study (NATO) demonstrated improved disease-free survival for NOLVADEX (tamoxifen citrate) compared to no adjuvant therapy following total mastectomy and axillary dissection in postmenopausal women with axillary node-negative breast cancer. In this study, the benefits of NOLVADEX (tamoxifen citrate) appeared to be independent of estrogen receptor status.

Duration of Therapy

In the EBCTCG 1995 overview, the reduction in recurrence and mortality was greater in those studies that used tamoxifen for about 5 years than in those that used tamoxifen for a shorter period of therapy.

In the NSABP B-14 trial, in which patients were randomized to NOLVADEX (tamoxifen citrate) 20 mg/day for 5 years vs. placebo and were disease-free at the end of this 5-year period were offered rerandomization to an additional 5 years of NOLVADEX (tamoxifen citrate) or placebo. With 4 years of follow-up after this rerandomization, 92% of the women that received 5 years of NOLVADEX (tamoxifen citrate) were alive and disease-free, compared to 86% of the women scheduled to receive 10 years of NOLVADEX (tamoxifen citrate) (p=0.003). Overall survivals were 96% and 94%, respectively (p=0.08). Results of the B-14 study suggest that continuation of therapy beyond 5 years does not provide additional benefit.

A Scottish trial of 5 years of tamoxifen vs. indefinite treatment found a disease-free survival of 70% in the five-year group and 61% in the indefinite group, with 6.2 years median follow-up (HR=1.27, 95% CI 0.87-1.85).

In a large randomized trial conducted by the Swedish Breast Cancer Cooperative Group of adjuvant NOLVADEX (tamoxifen citrate) 40 mg/day for 2 or 5 years, overall survival at 10 years was estimated to be 80% in the patients in the 5-year tamoxifen group, compared with 74% among corresponding patients in the 2-year treatment group (p=0.03). Disease-free survival at 10 years was 73% in the 5-year group and 67% in the 2-year group (p=0.009). Compared with 2 years of tamoxifen treatment, 5 years of treatment resulted in a slightly greater reduction in the incidence of contralateral breast cancer at 10 years, but this difference was not statistically significant.

Contralateral Breast Cancer

The incidence of contralateral breast cancer is reduced in breast cancer patients (premenopausal and postmenopausal) receiving NOLVADEX (tamoxifen citrate) compared to placebo. Data on contralateral breast cancer are available from 32,422 out of 36,689 patients in the 1995 overview analysis of the Early Breast Cancer Trialists Collaborative Group (EBCTCG). In clinical trials with NOLVADEX (tamoxifen citrate) of 1 year or less, 2 years, and about 5 years duration, the proportional reductions in the incidence rate of contralateral breast cancer among women receiving NOLVADEX (tamoxifen citrate) were 13% (NS), 26% (2p = 0.004) and 47% (2p < 0.00001), with a significant trend favoring longer tamoxifen duration (2p = 0.008). The proportional reductions in the incidence of contralateral breast cancer were independent of age and ER status of the primary tumor. Treatment with about 5 years of NOLVADEX (tamoxifen citrate) reduced the annual incidence rate of contralateral breast cancer from 7.6 per 1,000 patients in the control group compared with 3.9 per 1,000 patients in the tamoxifen group.

In a large randomized trial in Sweden (the Stockholm Trial) of adjuvant NOLVADEX (tamoxifen citrate) 40 mg/day for 2-5 years, the incidence of second primary breast tumors was reduced 40% (p < 0.008) on tamoxifen compared to control. In the NSABP B-14 trial in which patients were randomized to NOLVADEX (tamoxifen citrate) 20 mg/day for 5 years vs. placebo, the incidence of second primary breast cancers was also significantly reduced (p < 0.01). In NSABP B-14, the annual rate of contralateral breast cancer was 8.0 per 1000 patients in the placebo group compared with 5.0 per 1,000 patients in the tamoxifen group, at 10 years after first randomization.

Ductal Carcinoma in Situ

NSABP B-24, a double-blind, randomized trial included women with ductal carcinoma in situ (DCIS). This trial compared the addition of NOLVADEX (tamoxifen citrate) or placebo to treatment with lumpectomy and radiation therapy for women with DCIS. The primary objective was to determine whether 5 years of NOLVADEX (tamoxifen citrate) therapy (20 mg/day) would reduce the incidence of invasive breast cancer in the ipsilateral (the same) or contralateral (the opposite) breast.

In this trial 1,804 women were randomized to receive either NOLVADEX (tamoxifen citrate) or placebo for 5 years: 902 women were randomized to NOLVADEX (tamoxifen citrate) 10 mg tablets twice a day and 902 women were randomized to placebo. As of December 31, 1998, follow-up data were available for 1,798 women and the median duration of follow-up was 74 months.

The NOLVADEX (tamoxifen citrate) and placebo groups were well balanced for baseline demographic and prognostic factors. Over 80% of the tumors were less than or equal to 1 cm in their maximum dimension, were not palpable, and were detected by mammography alone. Over 60% of the study population was postmenopausal. In 16% of patients, the margin of the resected specimen was reported as being positive after surgery. Approximately half of the tumors were reported to contain comedo necrosis.

For the primary endpoint, the incidence of invasive breast cancer was reduced by 43% among women assigned to NOLVADEX (tamoxifen citrate) (44 cases - NOLVADEX (tamoxifen citrate) , 74 cases - placebo; p=0.004; relative risk (RR)=0.57, 95% CI: 0.39-0.84). No data are available regarding the ER status of the invasive cancers. The stage distribution of the invasive cancers at diagnosis was similar to that reported annually in the SEER data base.

Results are shown in Table 1. For each endpoint the following results are presented: the number of events and rate per 1,000 women per year for the placebo and NOLVADEX (tamoxifen citrate) groups; and the relative risk (RR) and its associated 95% confidence interval (CI) between NOLVADEX (tamoxifen citrate) and placebo. Relative risks less than 1.0 indicate a benefit of NOLVADEX (tamoxifen citrate) therapy. The limits of the confidence intervals can be used to assess the statistical significance of the benefits of NOLVADEX (tamoxifen citrate) therapy. If the upper limit of the CI is less than 1.0, then a statistically significant benefit exists.

Table 1. Major Outcomes of the NSABP B-24 Trial

Type of Event Lumpectomy, radiotherapy, and placebo Lumpectomy, radiotherapy, and NOLVADEX RR 95% CI Limits
  No. of events Rate per 1000 women per year No. of events Rate per 1000 women per year    
Invasive breast cancer (Primary endpoint) 74 16.73 44 9.60 0.57 0.39 to 0.84
  -Ipsilateral 47 10.61 27 5.90 0.56 0.33 to 0.91
  -Contralateral 25 5.64 17 3.71 0.66 0.33 to 1.27
  -Side undertermined 2 -- 0 -- --  
Secondary Endpoints
DCIS 56 12.66 41 8.95 0.71 0.46 to 1.08
  -Ipsilateral 46 10.40 38 8.29 0.88 0.51 to 1.25
  -Contralateral 10 2.26 3 0.65 0.29 0.05 to 1.13
All Breast Cancer Events 129 29.16 84 18.34 0.63 0.47 to 0.83
  -All ipsilateral events 96 21.70 65 14.19 0.65 0.47 to 0.91
  -All contralateral events 37 8.36 20 4.37 0.52 0.29 to 0.92
Deaths 32   28      
Uterine Malignancies1 4   9      
Endometrial Adenocarcinoma1 4 0.57 8 1.15    
Uterine Sarcoma1 0 0.0 1 0.14    
Second primary malignancies (other than endometrial and breast) 30   29      
Stroke 2   7      
Thromboembolic events (DVT, PE) 5   15      
1Updated follow-up data (median 8.1 years)

Survival was similar in the placebo and NOLVADEX (tamoxifen citrate) groups. At 5 years from study entry, survival was 97% for both groups.

Reduction in Breast Cancer Incidence in High Risk Women:

The Breast Cancer Prevention Trial (BCPT, NSABP P-1) was a double-blind, randomized, placebo-controlled trial with a primary objective to determine whether 5 years of NOLVADEX (tamoxifen citrate) therapy (20 mg/day) would reduce the incidence of invasive breast cancer in women at high risk for the disease (See INDICATIONS AND USAGE). Secondary objectives included an evaluation of the incidence of ischemic heart disease; the effects on the incidence of bone fractures; and other events that might be associated with the use of NOLVADEX (tamoxifen citrate) , including: endometrial cancer, pulmonary embolus, deep vein thrombosis, stroke, and cataract formation and surgery (See WARNINGS).

The Gail Model was used to calculate predicted breast cancer risk for women who were less than 60 years of age and did not have lobular carcinoma in situ (LCIS). The following risk factors were used: age; number of first-degree female relatives with breast cancer; previous breast biopsies; presence or absence of atypical hyperplasia; nulliparity; age at first live birth; and age at menarche. A 5-year predicted risk of breast cancer of ≥ 1.67% was required for entry into the trial.

In this trial, 13,388 women of at least 35 years of age were randomized to receive either NOLVADEX (tamoxifen citrate) or placebo for five years. The median duration of treatment was 3.5 years. As of January 31, 1998, follow-up data is available for 13,114 women. Twenty-seven percent of women randomized to placebo (1,782) and 24% of women randomized to NOLVADEX (tamoxifen citrate) (1,596) completed 5 years of therapy. The demographic characteristics of women on the trial with follow-up data are shown in Table 2.

Table 2. Demographic Characteristics of Women in the NSABP P-1 Trial

Characteristic Placebo Tamoxifen
  # % # %
Age (yrs.)
  35-39 184 3 158 2
  40-49 2,394 36 2,411 37
  50-59 2,011 31 2,019 31
  60-69 1,588 24 1,563 24
   ≥ 70 393 6 393 6
Age at first live birth (yrs.)
Nulliparous 1,202 18 1,205 18
  12-19 915 14 946 15
  20-24 2,448 37 2,449 37
  25-29 1,399 21 1,367 21
  ≥ 30 606 9 577 9
Race
White 6,333 96 6,323 96
Black 109 2 103 2
Other 128 2 118 2
Age at menarche
   ≥ 14 1,243 19 1,170 18
  12-13 3,610 55 3,610 55
   ≤ 11 1,717 26 1,764 27
# of first degree relatives with breast cancer
  0 1,584 24 1,525 23
  1 3,714 57 3,744 57
  2+ 1,272 19 1,275 20
Prior Hysterectomy
  No 4,173 63.5 4,018 62.4
  Yes 2,397 36.5 2,464 37.7
# of previous breast biopsies
  0 2,935 45 2,923 45
  1 1,833 28 1,850 28
   ≥ 2 1,802 27 1,771 27
History of atypical hyperplasia in the breast
  No 5,958 91 5,969 91
  Yes 612 9 575 9
History of LCIS at entry
  No 6,165 94 6,135 94
  Yes 405 6 409 6
5-year predicted breast cancer risk (%)
   ≤ 2.00 1,646 25 1,626 25
  2.01-3.00 2,028 31 2,057 31
  3.01-5.00 1,787 27 1,707 26
   ≥ 5.01 1,109 17 1,162 18
Total 6,570 100.0 6,544 100.0

Results are shown in Table 3. After a median follow-up of 4.2 years, the incidence of invasive breast cancer was reduced by 44% among women assigned to NOLVADEX (tamoxifen citrate) (86 cases-NOLVADEX (tamoxifen citrate) , 156 cases-placebo; p < 0.00001; relative risk (RR)=0.56, 95% CI: 0.43-0.72). A reduction in the incidence of breast cancer was seen in each prospectively specified age group ( ≤ 49, 50-59, ≥ 60), in women with or without LCIS, and in each of the absolute risk levels specified in Table 3. A non-significant decrease in the incidence of ductal carcinoma in situ (DCIS) was seen (23-NOLVADEX (tamoxifen citrate) , 35-placebo; RR=0.66; 95% CI: 0.39-1.11).

There was no statistically significant difference in the number of myocardial infarctions, severe angina, or acute ischemic cardiac events between the two groups (61-NOLVADEX (tamoxifen citrate) , 59-placebo; RR=1.04, 95% CI: 0.73-1.49).

No overall difference in mortality (53 deaths in NOLVADEX (tamoxifen citrate) group vs. 65 deaths in placebo group) was present. No difference in breast cancer-related mortality was observed (4 deaths in NOLVADEX (tamoxifen citrate) group vs. 5 deaths in placebo group).

Although there was a non-significant reduction in the number of hip fractures (9 on NOLVADEX (tamoxifen citrate) , 20 on placebo) in the NOLVADEX (tamoxifen citrate) group, the number of wrist fractures was similar in the two treatment groups (69 on NOLVADEX (tamoxifen citrate) , 74 on placebo). A subgroup analysis of the P-1 trial, suggests a difference in effect in bone mineral density (BMD) related to menopausal status in patients receiving NOLVADEX (tamoxifen citrate) . In postmenopausal women there was no evidence of bone loss of the lumbar spine and hip. Conversely, NOLVADEX (tamoxifen citrate) was associated with significant bone loss of the lumbar spine and hip in premenopausal women.

The risks of NOLVADEX (tamoxifen citrate) therapy include endometrial cancer, DVT, PE, stroke, cataract formation and cataract surgery (See Table 3). In the NSABP P-1 trial, 33 cases of endometrial cancer were observed in the NOLVADEX (tamoxifen citrate) group vs. 14 in the placebo group (RR=2.48, 95% CI: 1.27-4.92). Deep vein thrombosis was observed in 30 women receiving NOLVADEX (tamoxifen citrate) vs. 19 in women receiving placebo (RR=1.59, 95% CI: 0.86-2.98). Eighteen cases of pulmonary embolism were observed in the NOLVADEX (tamoxifen citrate) group vs. 6 in the placebo group (RR=3.01, 95% CI: 1.15-9.27). There were 34 strokes on the NOLVADEX (tamoxifen citrate) arm and 24 on the placebo arm (RR=1.42; 95% CI: 0.82-2.51). Cataract formation in women without cataracts at baseline was observed in 540 women taking NOLVADEX (tamoxifen citrate) vs. 483 women receiving placebo (RR=1.13, 95% CI: 1.00-1.28). Cataract surgery (with or without cataracts at baseline) was performed in 201 women taking NOLVADEX (tamoxifen citrate) vs. 129 women receiving placebo (RR=1.51, 95% CI: 1.21-1.89) (See WARNINGS).

Table 3 summarizes the major outcomes of the NSABP P-1 trial. For each endpoint, the following results are presented: the number of events and rate per 1000 women per year for the placebo and NOLVADEX (tamoxifen citrate) groups; and the relative risk (RR) and its associated 95% confidence interval (CI) between NOLVADEX (tamoxifen citrate) and placebo. Relative risks less than 1.0 indicate a benefit of NOLVADEX (tamoxifen citrate) therapy. The limits of the confidence intervals can be used to assess the statistical significance of the benefits or risks of NOLVADEX (tamoxifen citrate) therapy. If the upper limit of the CI is less than 1.0, then a statistically significant benefit exists.

For most participants, multiple risk factors would have been required for eligibility. This table considers risk factors individually, regardless of other co-existing risk factors, for women who developed breast cancer. The 5-year predicted absolute breast cancer risk accounts for multiple risk factors in an individual and should provide the best estimate of individual benefit (See INDICATIONS AND USAGE).

Table 3. Major Outcomes of the NSABP P-1 Trial

  # OF EVENTS RATE/1000 WOMEN/YEAR 95% CI
TYPE OF EVENT PLACEBO NOLVADEX PLACEBO NOLVADEX RR LIMITS
Invasive Breast Cancer 156 86 6.49 3.58 0.56 0.43-0.72
  Age ≤ 49 59 38 6.34 4.11 0.65 0.43-0.98
  Age 50-59 46 25 6.31 3.53 0.56 0.35-0.91
  Age ≥ 60 51 23 7.17 3.22 0.45 0.27-0.74
Risk Factors for Breast Cancer History, LCIS
  No 140 78 6.23 3.51 0.56 0.43-0.74
  Yes 16 8 12.73 6.33 0.50 0.21-1.17
History, Atypical Hyperplasia
  No 138 84 6.37 3.89 0.61 0.47-0.80
  Yes 18 2 8.69 1.05 0.12 0.03-0.52
No. First Degree Relatives
  0 32 17 5.97 3.26 0.55 0.30-0.98
  1 80 45 5.81 3.31 0.57 0.40-0.82
  2 35 18 8.92 4.67 0.52 0.30-0.92
≥ 3 9 6 13.33 7.58 0.57 0.20-1.59
5-Year Predicted Breast Cancer Risk (as calculated by the Gail Model)
   ≤ 2.00% 31 13 5.36 2.26 0.42 0.22-0.81
  2.01-3.00% 39 28 5.25 3.83 0.73 0.45-1.18
  3.01-5.00% 36 26 5.37 4.06 0.76 0.46-1.26
   ≥ 5.00% 50 19 13.15 4.71 0.36 0.21-0.61
DCIS 35 23 1.47 0.97 0.66 0.39-1.11
Fractures (protocol-specified sites) 921 761 3.87 3.20 0.61 0.83-1.12
  Hip 20 9 0.84 0.38 0.45 0.18-1.04
  Wrist2 74 69 3.11 2.91 0.93 0.67-1.29
Total Ischemic Events 59 61 2.47 2.57 1.04 0.71-1.51
  Myocardial Infarction 27 27 1.13 1.13 1.00 0.57-1.78
  Fatal 8 7 0.33 0.29 0.88 0.27-2.77
  Nonfatal 19 20 0.79 0.84 1.06 0.54-2.09
  Angina3 12 12 0.50 0.50 1.00 0.41-2.44
  Acute Ischemic Syndrome4 20 22 0.84 0.92 1.11 0.58-2.13
Uterine Malignancies (among women with an intact uterus)10 17 57        
  Endometrial Adenocarcinoma10 17 53 0.71 2.20    
  Uterine Sarcoma10 0 4 0.0 0.17    
Stroke5 24 34 1.00 1.43 1.42 0.82-2.51
Transient Ischemic Attack 21 18 0.88 0.75 0.86 0.43-1.70
Pulmonary Emboli6 6 18 0.25 0.75 3.01 1.15-9.27
Deep-Vein Thrombosis7 19 30 0.79 1.26 1.59 0.86-2.98
Cataracts Developing on Study8 483 540 22.51 25.41 1.13 1.00-1.28
Underwent Cataract Surgery8 63 101 2.83 4.57 1.62 1.18-2.22
Underwent Cataract Surgery9 129 201 5.44 8.56 1.58 1.26-1.97
1Two women had hip and wrist fractures
2 Includes Colles' and other lower radiusfractures
3Requiring angioplasty or CABG
4New Q-wave on ECG; no angina or elevation of serum enzymes; or angina requiring hospitalization without surgery
5Seven cases were fatal; three in the placebo group and four in the NOLVADEX (tamoxifen citrate) group
6Three cases in the NOLVADEX (tamoxifen citrate) group were fatal
7All but three cases in each group required hospitalization
8Based on women without cataracts at baseline (6,230-Placebo, 6,199-NOLVADEX (tamoxifen citrate) )
9All women (6,707-Placebo, 6,681-NOLVADEX (tamoxifen citrate) )
10Updated long-term follow-up data (median 6.9 years) from NSABP P-1 study added after cut-off for the other information in this table.

Table 4 describes the characteristics of the breast cancers in the NSABP P-1 trial and includes tumor size, nodal status, ER status. NOLVADEX (tamoxifen citrate) decreased the incidence of small estrogen receptor positive tumors, but did not alter the incidence of estrogen receptor negative tumors or larger tumors.

Table 4. Characteristics of Breast Cancer in NSABP P-1 Trial

Staging Parameter Placebo
N=156
Tamoxifen
N=86
Total
N=242
Tumor Size:
T1 117 60 177
T2 28 20 48
T3 7 3 10
T4 1 2 3
Unknown 3 1 4
Nodal status:
Negative 103 56 159
1-3 positive nodes 29 14 43
≥ 4 positive nodes 10 12 22
Unknown 14 4 18
Stage:
I 88 47 135
II: node negative 15 9 24
II: node positive 33 22 55
III 6 4 10
IV 21 1 3
Unknown 12 3 15
Estrogen receptor:
Positive 115 38 153
Negative 27 36 63
Unknown 14 12 26
1One participant presented with a suspicious bone scan but did not have documented metastases. She subsequently died of metastatic breast cancer.

Interim results from 2 trials in addition to the NSABP P-1 trial examining the effects of tamoxifen in reducing breast cancer incidence have been reported.

The first was the Italian Tamoxifen Prevention trial. In this trial women between the ages of 35 and 70, who had had a total hysterectomy, were randomized to receive 20 mg tamoxifen or matching placebo for 5 years. The primary endpoints were occurrence of, and death from, invasive breast cancer. Women without any specific risk factors for breast cancer were to be entered. Between 1992 and 1997, 5408 women were randomized. Hormone Replacement Therapy (HRT) was used in 14% of participants. The trial closed in 1997 due to the large number of dropouts during the first year of treatment (26%). After 46 months of follow-up there were 22 breast cancers in women on placebo and 19 in women on tamoxifen. Although no decrease in breast cancer incidence was observed, there was a trend for a reduction in breast cancer among women receiving protocol therapy for at least 1 year (19-placebo, 11- tamoxifen). The small numbers of participants along with the low level of risk in this otherwise healthy group precluded an adequate assessment of the effect of tamoxifen in reducing the incidence of breast cancer.

The second trial, the Royal Marsden Trial (RMT) was reported as an interim analysis. The RMT was begun in 1986 as a feasibility study of whether larger scale trials could be mounted. The trial was subsequently extended to a pilot trial to accrue additional participants to further assess the safety of tamoxifen. Twenty-four hundred and seventy-one women were entered between 1986 and 1996; they were selected on the basis of a family history of breast cancer. HRT was used in 40% of participants. In this trial, with a 70 month median follow-up, 34 and 36 breast cancers (8 noninvasive, 4 on each arm) were observed among women on tamoxifen and placebo, respectively. Patients in this trial were younger than those in the NSABP P-1 trial and may have been more likely to develop ER (-) tumors, which are unlikely to be reduced in number by tamoxifen therapy. Although women were selected on the basis of family history and were thought to have a high risk of breast cancer, few events occurred, reducing the statistical power of the study. These factors are potential reasons why the RMT may not have provided an adequate assessment of the effectiveness of tamoxifen in reducing the incidence of breast cancer.

In these trials, an increased number of cases of deep vein thrombosis, pulmonary embolus, stroke, and endometrial cancer were observed on the tamoxifen arm compared to the placebo arm. The frequency of events was consistent with the safety data observed in the NSABP P-1 trial.

McCune-Albright Syndrome

A single, uncontrolled multicenter trial of NOLVADEX (tamoxifen citrate) 20 mg once a day was conducted in a heterogenous group of girls with McCune-Albright Syndrome and precocious puberty manifested by physical signs of pubertal development, episodes of vaginal bleeding and/or advanced bone age (bone age of at least 12 months beyond chronological age). Twenty-eight female pediatric patients, aged 2 to 10 years, were treated for up to 12 months. Effect of treatment on frequency of vaginal bleeding, bone age advancement, and linear growth rate was assessed relative to prestudy baseline. NOLVADEX (tamoxifen citrate) treatment was associated with a 50% reduction in frequency of vaginal bleeding episodes by patient or family report (mean annualized frequency of 3.56 episodes at baseline and 1.73 episodes on-treatment). Among the patients who reported vaginal bleeding during the pre-study period, 62% (13 out of 21 patients) reported no bleeding for a 6-month period and 33% (7 out of 21 patients) reported no vaginal bleeding for the duration of the trial. Not all patients improved on treatment and a few patients not reporting vaginal bleeding in the 6 months prior to enrollment reported menses on treatment. NOLVADEX (tamoxifen citrate) therapy was associated with a reduction in mean rate of increase of bone age. Individual responses with regard to bone age advancement were highly heterogeneous. Linear growth rate was reduced during the course of NOLVADEX (tamoxifen citrate) treatment in a majority of patients (mean change of 1.68 cm/year relative to baseline; change from 7.47 cm/year at baseline to 5.79 cm/year on study). This change was not uniformly seen across all stages of bone maturity; all recorded response failures occurred in patients with bone ages less than 7 years at screening.

Mean uterine volume increased after 6 months of treatment and doubled at the end of the one-year study. A causal relationship has not been established; however, as an increase in the incidence of endometrial adenocarcinoma and uterine sarcoma has been noted in adults treated with NOLVADEX (see BOXED WARNING), continued monitoring of McCune-Albright patients treated with NOLVADEX (tamoxifen citrate) for long-term uterine effects is recommended. The safety and efficacy of NOLVADEX (tamoxifen citrate) for girls aged two to 10 years with McCune-Albright Syndrome and precocious puberty have not been studied beyond one year of treatment. The long-term effects of NOLVADEX (tamoxifen citrate) therapy in girls have not been established.

Last reviewed on RxList: 4/10/2008
This monograph has been modified to include the generic and brand name in many instances.

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