Norco (Hydrocodone Bitartrate and Acetaminophen) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

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Whiplash is a relatively common injury that occurs to a person's neck following a sudden acceleration-deceleration force, most commonly from motor vehicle accidents. The term "whiplash" was first used in 1928. The term "railway spine" was used to describe a similar condition that was common in persons involved in train accidents prior to 1928. The term "whiplash injury" describes damage to both the bone structures and soft tissues, while "whiplash associated disorders" describes a more severe and chronic condition.

Fortunately, whiplash is typically not a life threatening injury, but it can lead to a prolonged period of partial disability. There are significant economic expenses related to whiplash that can reach 30 billion dollars a year in the United States, including:

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NORCO® 7.5/325
(hydrocodone bitartrate and acetaminophen)
NORCO® 10/325
(hydrocodone bitartrate and acetaminophen) Tablet

DRUG DESCRIPTION

NORCO® (hydrocodone bitartrate and acetaminophen) is supplied in tablet form for oral administration.

Hydrocodone bitartrate is an opioid analgesic and antitussive and occurs as fine, white crystals or as a crystalline powder. It is affected by light. The chemical name is 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5). It has the following structural formula:

Hydrocodone bitartrate structural formula illustration

C₁₈H₂₁NO₃•C₄H₆O₆•2½H₂O M. W. = 494.49

Acetaminophen, 4´-Hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula:

Acetaminophen structural formula illustration

C₈H₉NO₂ M. W. = 151.16

NORCO (hydrocodone bitartrate and acetaminophen) ®, for oral administration is available in the following strengths:

	Hydrocodone Bitartrate	Acetaminophen
NORCO® 7.5/325	7.5 mg	325 mg
NORCO® 10/325	10 mg	325 mg

In addition, each tablet contains the following inactive ingredients: croscarmellose sodium, crospovidone, magnesium stearate, microcrystalline cellulose, povidone, pregelatinized starch, and stearic acid; the 7.5 mg/325 mg tablets include FD&C Yellow #6 Aluminum Lake, the 10 mg/325 mg tablets include D&C Yellow #10 Aluminum Lake. Meets USP Dissolution Test 1.

Last reviewed on RxList: 9/27/2010
This monograph has been modified to include the generic and brand name in many instances.