Norgesic (Orphenadrine Citrate with Aspirin and Caffeine) Drug Information: Clinical Pharmacology

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May 27, 2012

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Lower Back Pain »

Low back pain facts

Functions of the low back, or lumbar area, include structural support, movement, and protection of certain body tissues.
Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
Treatment of low back pain is optimally directed toward a diagnosed or suspected specific cause. For acute lumbar strain, use of a home remedy initially can be beneficial.

What is the anatomy of the low back?

The first step to understanding low back pain is appreciating the normal design (anatomy) of the tissues of this area of the body. Important structures of the low back that can be related to symptoms in this region include the bony lumbar spine (vertebrae, singular = vert...

Read the Lower Back Pain article »

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CLINICAL PHARMACOLOGY

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Orphenadrine citrate is a centrally acting (brain stem) compound which in animals selectively blocks facilitatory functions of the reticular formation. Orphenadrine does not produce myoneural block, nor does it affect crossed extensor reflexes. Orphenadrine prevents nicotine-induced convulsions but not those produced by strychnine.

Chronic administration of Norgesic (orphenadrine citrate with aspirin and caffeine) to dogs and rats has revealed no drug-related toxicity. No blood or urine changes were observed, nor were there any macroscopic or microscopic pathological changes detected. Extensive experience with combinations containing aspirin and caffeine has established them as safe agents. The addition of orphenadrine citrate does not alter the toxicity of aspirin and caffeine.

The mode of therapeutic action of orphenadrine has not been clearly identified, but may be related to its analgesic properties.

Orphenadrine citrate also possesses anticholinergic actions.

Last reviewed on RxList: 4/7/2009
This monograph has been modified to include the generic and brand name in many instances.