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Norgesic Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Norgesic (orphenadrine citrate, aspirin and caffeine) is used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Orphenadrine is a muscle relaxant, aspirin is a pain reliever, and caffeine is used in this combination to increase the pain relieving effects of aspirin and orphenadrine. This medication is available in generic form. Common side effects include dizziness, drowsiness, blurred vision, weakness, headache, stomach upset, heartburn, nausea, constipation, and dry mouth.
The adult dose of Norgesic is 1 to 2 tablets, 3 to 4 times daily. The adult dose of Norgesic Forte is ½ to 1 tablet 3 to 4 times daily. Norgesic may interact with antidepressants, alcohol, antihistamines, sedatives, other pain relievers, anxiety medicines, muscle relaxants, anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), or other salicylates. Tell your doctor all medications you use. During pregnancy, Norgesic should be used only when prescribed. Aspirin is not recommended for use during pregnancy. This medication passes into breast milk and may harm a nursing infant. Breastfeeding while using this drug is not recommended.
Our Norgesic (orphenadrine citrate, aspirin and caffeine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Norgesic in Detail - Patient Information: Side Effects
If you experience any of the following serious side effects, stop taking aspirin/caffeine/orphenadrine and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- an irregular or a very fast heartbeat;
- confusion, hallucinations, or abnormal behavior;
- red, black, or bloody stools; or
- blood in vomit.
Other, less serious side effects may be more likely to occur. Continue to take aspirin/caffeine/orphenadrine and talk to your doctor if you experience
- drowsiness or dizziness;
- blurred vision or large pupils;
- difficulty urinating;
- faint ringing in the ears; or
- nausea, vomiting, or constipation.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Norgesic (Orphenadrine Citrate with Aspirin and Caffeine) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Norgesic Overview - Patient Information: Side Effects
To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as confusion, anxiety, hallucinations, nervousness, agitation), shaking (tremor), fast/pounding/irregular heartbeat, hearing changes (such as ringing in the ears, difficulty hearing), difficulty urinating, easy bleeding/bruising, fainting, eye pain, unusual tiredness, change in the amount of urine, yellowing eyes/skin, dark urine.
This drug may infrequently cause serious (rarely fatal) bleeding from the stomach or intestines. If you notice any of the following unlikely but serious side effects, stop taking this medication and consult your doctor or pharmacist immediately: black stools, vomit that looks like coffee grounds, persistent stomach/abdominal pain.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing trouble.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Norgesic (Orphenadrine Citrate with Aspirin and Caffeine)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Norgesic FDA Prescribing Information: Side Effects
Side effects of Norgesic (orphenadrine citrate with aspirin and caffeine) or Norgesic (orphenadrine citrate with aspirin and caffeine) Forte are those seen with aspirin and caffeine or those usually associated with mild anticholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilatation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, and rarely, urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of confusion. Mild central excitation and occasional hallucinations may be observed. These mild side effects can usually be eliminated by reduction in dosage. One case of aplastic anemia associated with the use of Norgesic (orphenadrine citrate with aspirin and caffeine) has been reported. No causal relationship has been established. Rare G.I. hemorrhage due to aspirin content may be associated with the administration of Norgesic (orphenadrine citrate with aspirin and caffeine) or Norgesic (orphenadrine citrate with aspirin and caffeine) Forte. Some patients may experience transient episodes of light-headedness, dizziness or syncope.
Read the entire FDA prescribing information for Norgesic (Orphenadrine Citrate with Aspirin and Caffeine) »
Additional Norgesic Information
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