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Norpace Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Norpace (disopyramide phosphate) is used to treat seriously irregular heartbeat patterns. It is an anti-arrhythmic drug. This medication is available in generic form. Common side effects include dry mouth, constipation, nausea, abdominal pain/gas/bloating, blurred vision, dry nose/eyes/throat, and urination problems (such as difficulty urinating or unusual frequent urge to urinate).
The usual adult dosage of Norpace or Norpace CR is 400 to 800 mg per day given in divided doses. Norpace may interact with other anti-arrhythmics, beta-blockers, erythromycin, clarithromycin, phenytoin, phenobarbital, cisapride, rifampin, or warfarin. Tell your doctor all medications you use. During pregnancy, Norpace should be used only when prescribed. Rarely, this drug may cause early labor during pregnancy. Discuss the risks and benefits with your doctor. This medication passes into breast milk, and the effect on a nursing infant is unknown. Consult your doctor before breast-feeding.
Our Norpace (disopyramide phosphate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Norpace in Detail - Patient Information: Side Effects
If you experience any of the following serious side effects, stop taking disopyramide and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- a new or a worsening irregular heartbeat pattern;
- chest pain, chest discomfort, shortness of breath, or swelling of your legs or feet; or
- severe dizziness.
Other, less serious side effects may be more likely to occur. Talk to your doctor if you experience
- mild dizziness or tiredness,
- blurred vision,
- dry mouth,
- rash, itching,
- muscle aches or pains, or
- difficulty urinating.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Norpace (Disopyramide Phosphate) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Norpace Overview - Patient Information: Side Effects
Dry mouth, constipation, nausea, abdominal pain/gas/bloating, blurred vision, dry nose/eyes/throat, and urination problems (such as difficulty urinating or unusual frequent urge to urinate) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these rare but serious side effects occur: symptoms of low blood sugar (such as shakiness with unusual hunger/headache/sweating), signs of liver problems (such as persistent nausea/vomiting, stomach/abdominal pain, yellowing eyes/skin, dark urine), muscle weakness, worsening symptoms of heart failure (such as ankle/leg swelling, increased tiredness, increased shortness of breath when lying down).
Seek immediate medical attention if any of these rare but serious side effects occur: fainting, faster/more irregular heartbeat, severe dizziness.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Norpace (Disopyramide Phosphate)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Norpace FDA Prescribing Information: Side Effects
The adverse reactions which were reported in Nor-pace clinical trials encompass observations in 1,500 patients, including 90 patients studied for at least 4 years. The most serious adverse reactions are hypo-tension and congestive heart failure. The most common adverse reactions, which are dose dependent, are associated with the anticholinergic properties of the drug. These may be transitory, but may be persistent or can be severe. Urinary retention is the most serious anticholinergic effect.
The following reactions were reported in 10% to 40% of patients:
Anticholinergic: dry mouth (32%), urinary hesitancy (14%), constipation (11%)
The following reactions were reported in 3% to 9% of patients:
Genitourinary: urinary retention, urinary frequency and urgency
Gastrointestinal: nausea, pain/bloating/gas
General: dizziness, general fatigue/muscle weakness, headache, malaise, aches/pains
The following reactions were reported in 1% to 3% of patients:
Cardiovascular: hypotension with or without congestive heart failure, increased congestive heart failure (see WARNINGS), cardiac conduction disturbances (see WARNINGS), edema/weight gain, shortness of breath, syncope, chest pain
Dermatologic: generalized rash/dermatoses, itching
Central nervous system: nervousness
Other: hypokalemia, elevated cholesterol/triglycerides
The following reactions were reported in less than 1%:
Depression, insomnia, dysuria, numbness/tingling, elevated liver enzymes, AV block, elevated BUN, elevated creatinine, decreased hemoglobin/hematocrit Hypoglycemia has been reported in association with Norpace administration (see WARNINGS).
Infrequent occurrences of reversible cholestatic jaundice, fever, and respiratory difficulty have been reported in association with disopyramide therapy, as have rare instances of thrombocytopenia, reversible agranulocytosis, and gynecomastia. Some cases of LE (lupus erythematosus) symptoms have been reported; most cases occurred in patients who had been switched to disopyramide from procaina-mide following the development of LE symptoms. Rarely, acute psychosis has been reported following Norpace (disopyramide phosphate) therapy, with prompt return to normal mental status when therapy was stopped. The physician should be aware of these possible reactions and should discontinue Norpace (disopyramide phosphate) or Norpace (disopyramide phosphate) CR therapy promptly if they occur.
Read the entire FDA prescribing information for Norpace (Disopyramide Phosphate) »
Additional Norpace Information
Norpace - User Reviews
Norpace User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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