September 24, 2016
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"The U.S. Food and Drug Administration today approved Northera capsules (droxidopa) for the treatment of neurogenic orthostatic hypotension (NOH). NOH is a rare, chronic and often debilitating drop in blood pressure upon standing that is associate"...




Elevations In Blood Pressure

Counsel patients that NORTHERA causes elevations in blood pressure and increases the risk of supine hypertension, which could lead to strokes, heart attacks, and death. Instruct patients to rest and sleep in an upper-body elevated position and monitor blood pressure. Instruct patients how to manage observed blood pressure elevations. To reduce the risk of supine hypertension, in addition to raising the upper body, the late afternoon dose of NORTHERA should be taken at least three hours before bedtime.

Concomitant Treatments

Counsel patients about the concomitant use of drugs to treat other conditions that may have an additive effect with NORTHERA [see DRUG INTERACTIONS].


Counsel patients to consult a physician if they are nursing, pregnant, or planning to become pregnant while taking NORTHERA.


Patients should take NORTHERA the same way each time, either with food or without food.

Missed Dose

If a dose is missed, patients should take the next dose at the regularly scheduled time and should not double the dose.

Last reviewed on RxList: 4/28/2016
This monograph has been modified to include the generic and brand name in many instances.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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