May 26, 2017
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"The U.S. Food and Drug Administration today approved Northera capsules (droxidopa) for the treatment of neurogenic orthostatic hypotension (NOH). NOH is a rare, chronic and often debilitating drop in blood pressure upon standing that is associate"...




Elevations In Blood Pressure

Counsel patients that NORTHERA causes elevations in blood pressure and increases the risk of supine hypertension, which could lead to strokes, heart attacks, and death. Instruct patients to rest and sleep in an upper-body elevated position and monitor blood pressure. Instruct patients how to manage observed blood pressure elevations. To reduce the risk of supine hypertension, in addition to raising the upper body, the late afternoon dose of NORTHERA should be taken at least three hours before bedtime [see WARNINGS AND PRECAUTIONS].

Concomitant Treatments

Counsel patients about the concomitant use of drugs to treat other conditions that may have an additive effect with NORTHERA [see DRUG INTERACTIONS].

Allergic Reactions

Counsel patients to discontinue NORTHERA and seek immediate medical attention if any signs or symptoms of a hypersensitivity reaction such as anaphylaxis, angioedema, bronchospasm, urticaria or rash occur [see WARNINGS AND PRECAUTIONS].


Advise women not to breastfeed during treatment with NORTHERA [see Use in Specific Populations].


Patients should take NORTHERA the same way each time, either with food or without food [see DOSAGE AND ADMINISTRATION].

Missed Dose

If a dose is missed, patients should take the next dose at the regularly scheduled time and should not double the dose.

Last reviewed on RxList: 2/24/2017
This monograph has been modified to include the generic and brand name in many instances.

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