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Nortriptyline Hydrochloride

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Nortriptyline Hydrochloride

CLINICAL PHARMACOLOGY

The mechanism of mood elevation by tricyclic antidepressants is at present unknown. Nortriptyline hydrochloride (nortriptyline hydrochloride (nortriptyline hydrochloride (nortriptyline hydrochloride capsules) capsules) capsules) is not a monoamine oxidase inhibitor. It inhibits the activity of such diverse agents as histamine, 5-hydroxytryptamine, and acetylcholine. It increases the pressor effect of norepinephrine but blocks the pressor response of phenethylamine. Studies suggest that nortriptyline hydrochloride (nortriptyline hydrochloride (nortriptyline hydrochloride (nortriptyline hydrochloride capsules) capsules) capsules) interferes with the transport, release, and storage of catecholamines. Operant conditioning techniques in rats and pigeons suggest that nortriptyline hydrochloride (nortriptyline hydrochloride capsules) has a combination of stimulant and depressant properties.

Last reviewed on RxList: 4/17/2008
This monograph has been modified to include the generic and brand name in many instances.

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