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Nortriptyline Hydrochloride Oral Solution

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Nortriptyline Hydrochloride Oral Solution

CLINICAL PHARMACOLOGY

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The mood elevating mechanism of tricyclic antidepressants is at present unknown. Nortriptyline hydrochloride is not a monoamine oxidase inhibitor. It inhibits the activity of such diverse agents as histamine, 5-hydroxytryptamine, and acetylcholine. It increases the pressor effect of norepinephrine but blocks the pressor response of phenethylamine. Studies suggest that nortriptyline hydrochloride interferes with the transport, release, and storage of catecholamines. Operant conditioning techniques in rats and pigeons suggest that nortriptyline hydrochloride has a combination of stimulant and depressant properties.

Last reviewed on RxList: 4/18/2008
This monograph has been modified to include the generic and brand name in many instances.

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