August 1, 2015
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Novolin R

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Novolin R

Novolin R Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Novolin R (regular, human insulin [rDNA origin]) is used to control blood sugar in patients with diabetes mellitus. Insulin is a naturally occurring hormone. This medication is available over-the-counter. Side effects include high or low blood sugar, and injection site reactions such as redness, swelling, and itching.

The dosing of Novolin R is individualized. It is usually given three or more times daily before meals. Novolin R may interact with oral hypoglycemic agents (OHA), octreotide, monoamine oxidase inhibitors (MAOIs), beta-blockers, ACE inhibitors, salicylates, alcohol, antibiotics, steroids, quinine, quinidine, alpha-blockers, oral contraceptives, thiazides, glucocorticoids, thryroid hormones and sympathomimetics, growth hormone, diazoxide, asparaginase, and nicotinic acid. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Novolin R. Consult your doctor before breastfeeding.

Our Novolin R (regular, human insulin [rDNA origin]) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Novolin R in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out.

Hypoglycemia, or low blood sugar, is the most common side effect of insulin. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

Tell your doctor if you have itching, swelling, redness, or thickening of the skin where you inject insulin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Novolin R (Recombinant DNA Origin)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Novolin R FDA Prescribing Information: Side Effects
(Adverse Reactions)


Adverse events commonly associated with human insulin therapy include the following:

Body as Whole - Allergic reactions (see PRECAUTIONS, Allergy).

Skin and Appendages - Injection site reaction, lipodystrophy, pruritus, rash (see PRECAUTIONS, Allergy).

Other - Hypoglycemia, Hyperglycemia and ketosis (see PRECAUTIONS)

Read the entire FDA prescribing information for Novolin R (Recombinant DNA Origin)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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