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Novolog Mix 50-50

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NovoLog Mix 50/50

NovoLog® Mix 50/50
50% insulin aspart protamine suspension and 50% insulin aspart injection, (rDNA origin)

DRUG DESCRIPTION

NovoLog® Mix 50/50 (50% insulin aspart protamine suspension and 50% insulin aspart injection) (50% insulin aspart protamine suspension and 50% insulin aspart injection, [rDNA origin]) is an insulin analog suspension containing 50% insulin aspart protamine crystals and 50% soluble insulin aspart. NovoLog® Mix 50/50 is a blood glucose-lowering agent with a rapid onset and an intermediate duration of action. Insulin aspart is homologous with regular human insulin with the exception of a single substitution of the amino acid proline by aspartic acid in position B28, and is produced by recombinant DNA technology utilizing Saccharomyces cerevisiae (baker's yeast) as the on organism. Insulin aspart (NovoLog® ) has the empirical formula C256H381N65O79S6 and a molecular weight of 5825.8 Da.

Structural formula:

NovoLog®  (50% insulin aspart protamine suspension and 50% insulin aspart injection, [rDNA origin])  Structural Formula Illustration

NovoLog® Mix 50/50 (50% insulin aspart protamine suspension and 50% insulin aspart injection) is a uniform, white, sterile suspension that contains insulin aspart (B28 asp regular human insulin analog) 100 Units/ml, 16 mg glycerol, 1.50 mg phenol, 1.72 mg metacre­sol, 19.6 μg zinc, 1.25 mg disodium hydrogen phosphate dihydrate, 1.17 mg sodium chloride, and 0.23 mg protamine sulfate. NovoLog® Mix 50/50 (50% insulin aspart protamine suspension and 50% insulin aspart injection) has a pH of 7.10 - 7.44. Hydrochloric acid or sodium hydroxide may be added to adjust pH.

Last reviewed on RxList: 9/30/2008
This monograph has been modified to include the generic and brand name in many instances.

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