May 1, 2016
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Novolog Mix 50-50

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NovoLog Mix 50/50

Novolog Mix 50-50 Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

NovoLog Mix 50/50 (50% insulin aspart protamine suspension and 50% insulin aspart injection) is a form of insulin used as an adjunct to diet and exercise to improve glycemic control in patients with diabetes mellitus. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include allergic reactions, and injection site reactions such as itching or rash.

Dose regimens of NovoLog Mix 50/50 will vary among patients and should be determined by the physician familiar with the patient's lifestyle variables. NovoLog Mix 50/50 may interact with oral antidiabetic products, other insulin products, pramlintide, ACE inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase (MAO) inhibitors, propoxyphene, salicylates, somatostatin analog, antibiotics, corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazines, somatropin, thyroid hormones, estrogens, oral contraceptives, beta-blockers, clonidine, lithium, alcohol, pentamidine, clonidine, guanethidine, and reserpine. Tell your doctor all medications and supplements you use. During pregnancy, NovoLog Mix 50/50 should be used only if prescribed. Talk to your doctor about your insulin needs during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our NovoLog Mix 50/50 (50% insulin aspart protamine suspension and 50% insulin aspart injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Novolog Mix 50-50 FDA Prescribing Information: Side Effects
(Adverse Reactions)


During clinical trials the overall adverse event profile of NovoLog® Mix 50/50 was comparable to Novolin® 70/30.

Adverse events commonly associated with human insulin therapy include the following:

Body as whole: allergic reactions (see PRECAUTIONS, Allergy).

Skin and Appendages: Injection site reaction, lipodystrophy, pruritus, rash (see PRECAUTIONS, Allergy).

Hypoglycemia: see WARNINGS and PRECAUTIONS.

Read the entire FDA prescribing information for Novolog Mix 50-50 (50% Insulin Aspart Protamine Suspension and 50% Insulin Aspart Injection)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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