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Novolog Mix 70-30

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NovoLog Mix 70/30

NovoLog Mix 70/30

PATIENT INFORMATION

NovoLog® Mix 70/30
(70% insulin aspart protamine suspension and 30% insulin aspart) Injection, [rDNA origin]

Read the Patient Information leaflet that comes with NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) before you start taking it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your healthcare provider about your diabetes or your treatment. Make sure you know how to manage your diabetes. Ask your healthcare provider if you have any questions about managing your diabetes.

What is NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) ?

NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) is a man-made insulin that is used to control high blood sugar in adults with diabetes mellitus.

It is not known if NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) is safe or effective in children.

Who should not use NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) ?

Do not take NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) if:

  • Your blood sugar is too low (hypoglycemia)
  • You are allergic to any of the ingredients in NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) . See the end of this leaflet for a complete list of ingredients in NovoLog® Mix 70/30. Check with your healthcare provider if you are not sure.

What should I tell my healthcare provider before taking NovoLog® Mix 70/30?

Before you use NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) , tell your healthcare provider if you:

  • have kidney or liver problems
  • have any other medical conditions. Medical conditions can affect your insulin needs and your dose of NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) .
  • are pregnant or plan to become pregnant. It is not known if NovoLog® Mix 70/30 will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant. You and your healthcare provider should decide about the best way to manage your diabetes while you are pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if NovoLog® Mix 70/30 passes into your breast milk. You and your healthcare provider should decide if you will take NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) while you breastfeed.

Tell your healthcare provider about all medicines you take, including prescriptions and non-prescription medicines, vitamins and herbal supplements.

NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) may affect the way other medicines work, and other medicines may affect how NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) works. Your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) dose may change if you take other medicines.

Know the medicines you take. Keep a list of your medicines with you to show your healthcare providers and pharmacist when you get a new medicine.

How should I take NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) ?

  • Take NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) exactly as your healthcare provider tells you to take it.
  • Your healthcare provider will tell you how much NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) to take and when to take it.
  • Do not make any changes to your dose or type of insulin unless your healthcare provider tells you to.
  • NovoLog Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) starts acting fast. If you have Type 1 diabetes, inject it up to 15 minutes before you eat a meal. Do not inject NovoLog® Mix 70/30 if you are not planning to eat within 15 minutes.
  • If you have Type 2 diabetes, you may inject NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) up to 15 minutes before or after starting your meal.
  • Do Not mix NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) with other insulin products.
  • Do Not use NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) in an insulin pump.
  • Inject NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) under the skin (subcutaneously) of your stomach area, upper arms, buttocks or upper legs. NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) may affect your blood sugar levels faster if you inject it under the skin of your stomach area. Never inject NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) into a vein or into a muscle.
  • Change (rotate) injection sites within the area you choose with each dose. Do not inject into the exact same spot for each injection.
  • Read the instructions for use that come with your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) . Talk to your healthcare provider if you have any questions. Your healthcare provider should show you how to inject NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) before you start using it.
  • NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) comes in:
    • 10 mL vials for use with a syringe
    • 3 mL NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen®
  • If you take too much NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) , your blood sugar may fall too low (hypoglycemia). You can treat mild low blood sugar (hypoglycemia) by drinking or eating something sugary right away (fruit juice, sugar candies, or glucose tablets). It is important to treat low blood sugar (hypoglycemia) right away because it could get worse and you could pass out (loss of consciousness).
  • If you forget to take your dose of NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) , your blood sugar may go too high (hyperglycemia). If high blood sugar (hyperglycemia) is not treated it can lead to serious problems, like passing out (loss of consciousness), coma or even death. Follow your healthcare provider's instructions for treating high blood sugar. Know your symptoms of high blood sugar which may include:

  • increased thirst
  • frequent urination
  • drowsiness
  • loss of appetite
  • a hard time breathing
  • fruity smell on the breath
  • high amounts of sugar and ketones in your urine
  • nausea, vomiting (throwing up) or stomach pain

  • Do not share needles, insulin pens or syringes with others.
  • Check your blood sugar levels. Ask your healthcare provider what your blood sugars should be and when you should check your blood sugar levels.

Your insulin dosage may need to change because of:

  • illness
  • stress
  • other medicines you take
  • change in diet
  • change in physical activity or exercise

 See the end of this patient information for instructions about preparing and giving your injection.

What should I consider while using NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) ?

  • Alcohol. Drinking alcohol may affect your blood sugar when you take NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) .
  • Driving and operating machinery. You may have trouble paying attention or reacting if you have low blood sugar (hypoglycemia). Be careful when you drive a car or operate machinery. Ask your healthcare provider if it is alright for you to drive if you often have:
    • low blood sugar
    • decreased or no warning signs of low blood sugar

What are the possible side effects of NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) ?

NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) may cause serious side effects, including:

  • low blood sugar (hypoglycemia). Symptoms of low blood sugar may include:

  • sweating
  • dizziness or lightheadedness
  • shakiness
  • hunger
  • fast heart beat
  • tingling of lips and tongue
  • trouble concentrating or confusion
  • blurred vision
  • slurred speech
  • anxiety, irritability or mood changes
  • headache

Very low blood sugar can cause you to pass out (loss of consciousness), seizures, and death. Talk to your healthcare provider about how to tell if you have low blood sugar and what to do if this happens while taking NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) . Know your symptoms of low blood sugar. Follow your healthcare provider's instructions for treating low blood sugar.

Talk to your healthcare provider if low blood sugar is a problem for you. Your dose of NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) may need to be changed.

  • Low potassium in your blood (hypokalemia)
  • Reactions at the injection site (local allergic reaction). You may get redness, swelling, and itching at the injection site. If you keep having skin reactions or they are serious talk to your healthcare provider.
  • Serious allergic reaction (whole body reaction). Get medical help right away, if you have any of these symptoms of an allergic reaction:
    • a rash over your whole body
    • have trouble breathing
    • a fast heartbeat
    • sweating
    • feel faint

The most common side effects of NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) include:

  • Skin thickening or pits at the injection site (lipodystrophy). Change (rotate) where you inject your insulin to help to prevent these skin changes from happening. Do not inject insulin into this type of skin.
  • Weight gain
  • Swelling of your hands and feet
  • Vision changes

These are not all of the possible side effects from NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) . Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) ?

All Unopened NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) :

  • Keep all unopened NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Do not freeze or store next to the refrigerator cooling element. Do not use NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) if it has been frozen.
  • Keep unopened NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) in the carton to protect from light.
  • Unopened vials can be used until the expiration date on the NovoLog® Mix 70/30 label, if the medicine has been stored in a refrigerator.
  • Unused NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® can be used until the expiration date on the NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® label, if the medicine has been stored in a refrigerator.

After NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) has been opened:

  • Vials
    • Keep in the refrigerator or at room temperature below 86°F (30°C) for up to 28 days.
    • Keep vials away from direct heat or light.
    • Throw away an opened vial after 28 days of use, even if there is insulin left in the vial.
  • NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen®
    • Keep at room temperature below 86°F (30°C) for up to 14 days.
    • Do not store a NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® that you are using in the refrigerator.
    • Keep NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® away from direct heat or light.
    • Throw away a used NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® after 14 days, even if there is insulin left in the syringe.

Never use insulin after the expiration date that is printed on the label and carton.

Keep NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) and all medicines out of the reach of children.

General advice about NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin))

Medicines are sometimes prescribed for conditions that are not mentioned in the patient leaflet. Do not use NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) for a condition for which it was not prescribed. Do not give NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) to other people, even if they have the same symptoms you have. It may harm them.

This leaflet summarizes the most important information about NovoLog® Mix 70/30. If you would like more information about NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) or diabetes, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) that is written for healthcare professionals. For more information call 1-800-7276500 or go to www.novonordisk-us.com.

What are the ingredients in NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) ?

  • Active Ingredients NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® and Vial: 70% Insulin aspart protamine suspension and 30% insulin aspart injection (rDNA origin).
  • Inactive Ingredients NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen®: glycerol, phenol, metacresol, zinc, disodium hydrogen phosphate dihydrate, sodium chloride, protamine sulfate, water for injection, hydrochloric acid or sodium hydroxide.
  • Inactive Ingredients NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) Vial: mannitol, phenol, metacresol, zinc, disodium hydrogen phosphate dihydrate, sodium chloride, protamine sulfate, water for injection, hydrochloric acid or sodium hydroxide.

All NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) vials and NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® are latex free.

Helpful information for people with diabetes is published by the American Diabetes Association, 1701 N Beauregard Street, Alexandria, VA 2311 and is available at www.diabetes.org.

Patient Instructions for Use

NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen®

Read the following instructions carefully before you start using your NovoLog® Mix 70/30 FlexPen® and each time you get a refill. There may be new information. You should read the instructions even if you have used Novolog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® before.

NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® is a disposable dial-a-dose insulin pen. You can select doses from 1 to 60 units in increments of 1 unit. NovoLog® Mix 70/30 FlexPen® is designed to be used with NovoFine® needles.

NovoLog Mix® 70/30 FlexPen® should not be used by people who are blind or have severe visual problems without the help of a person who has good eyesight and who is trained to use the NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® the right way.

Getting ready

Make sure you have the following items:

  • NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen®
  • New NovoFine® needle
  • Alcohol swab

NovoLog® Mix 70/30 FlexPen - Illustration

PREPARING YOUR NOVOLOG® MIX 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FLEXPEN®

  • Wash your hands with soap and water.
  • Before you start to prepare your injection, check the label to make sure that you are taking the right type of insulin. This is especially important if you take more than 1 type of insulin. NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) should look cloudy after mixing.

Before your first injection with a new NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® you must mix the insulin:

A. Let the insulin reach room temperature before you use it. This makes it easier to mix.

Pull off the pen cap (see diagram A).

Pull off the pen cap - Illustration

B. Roll the pen between your palms 10 times – it is important that the pen is kept horizontal (see diagram B).

Roll the pen between your palms 10 times - Illustration

C. Then gently move the pen up and down ten times between position 1 and 2 as shown, so the glass ball moves from one end of the cartridge to the other (see diagram C).

Then gently move the pen up and down ten times - Illustration

Repeat rolling and moving the pen until the liquid appears white and cloudy.

For every following injection move the pen up and down between positions 1 and 2 at least ten times until the liquid appears white and cloudy.

After mixing, complete all the following steps of the injection right away. If there is a delay, the insulin will need to be mixed again.

Wipe the rubber stopper with an alcohol swab.

Before you inject, there must be at least 12 units of insulin left in the cartridge to make sure the remaining insulin is evenly mixed. If there are less than 12 units left, use a new NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® .

Attaching the needle

D. Remove the protective tab from a disposable needle.

Remove the protective tab - Illustration

Screw the needle tightly onto your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® . It is important that the needle is put on straight (see diagram D).

Never place a disposable needle on your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® until you are ready to take your injection.

E. Pull off the big outer needle cap (see diagram E).

Pull off the big outer needle cap - Illustration

F. Pull off the inner needle cap and dispose of it (see diagram F).

Pull off the inner needle cap - Illustration

  • Always use a new needle for each injection to help ensure sterility and prevent blocked needles.
  • Be careful not to bend or damage the needle before use.
  • To reduce the risk of a needle stick, never put the inner needle cap back on the needle.

Giving the airshot before each injection:

Before each injection small amounts of air may collect in the cartridge during normal use. To avoid injecting air and to make sure you take the right dose of insulin:

G. Turn the dose selector to select 2 units (see diagram G).

Turn the dose selector - Illustration

H. Hold your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® with the needle pointing up. Tap the cartridge gently with your finger a few times to make any air bubbles collect at the top of the cartridge (see diagram H).

Tap the cartridge gently - Illustration

I. Keep the needle pointing upwards, press the push-button all the way in (see diagram I). The dose selector returns to 0.

press the push-button all the way in - Illustration

A drop of insulin should appear at the needle tip. If not, change the needle and repeat the procedure no more than 6 times.

If you do not see a drop of insulin after 6 times, do not use the NovoLog Mix® 70/30 FlexPen® and contact Novo Nordisk at 1-800-727-6500.

A small air bubble may remain at the needle tip, but it will not be injected.

SELECTING YOUR DOSE

Check and make sure that the dose selector is set at 0.

J. Turn the dose selector to the number of units you need to inject. The pointer should line up with your dose.

Turn the dose selector - Illustration

The dose can be corrected either up or down by turning the dose selector in either direction until the correct dose lines up with the pointer (see diagram J). When turning the dose selector, be careful not to press the push-button as insulin will come out.

You cannot select a dose larger than the number of units left in the cartridge.

You will hear a click for every single unit dialed. Do not set the dose by counting the number of clicks you hear.

  • Do not use the cartridge scale printed on the cartridge to measure your dose of insulin.

GIVING THE INJECTION

Do the injection exactly as shown to you by your healthcare provider. Your healthcare provider should tell you if you need to pinch the skin before injecting. Wipe the skin with an alcohol swab and let the area dry.

K. Insert the needle into your skin.

Insert the needle into your skin - Illustration

Inject the dose by pressing the push-button all the way in until the 0 lines up with the pointer (see diagram K). Be careful only to push the button when injecting.

Turning the dose selector will not inject insulin.

L. Keep the needle in the skin for at least 6 seconds, and keep the push-button pressed all the way in until the needle has been pulled out from the skin (see diagram L). This will make sure that the full dose has been given.

keep the push-button pressed all the way in - Illustration

You may see a drop of NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) at the needle tip. This is normal and has no effect on the dose you just received. If blood appears after you take the needle out of your skin, press the injection site lightly with an alcohol swab. Do not rub the area.

After the injection

Do not recap the needle. Recapping can lead to a needle stick injury. Remove the needle from the NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® after each injection. This helps to prevent infection, leakage of insulin, and will help to make sure you inject the right dose of insulin.

  • Put the needle and any empty NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® or any used NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® still containing insulin in a sharps container or some type of hard plastic or metal container with a screw top such as a detergent bottle or empty coffee can. These containers should be sealed and thrown away the right way. Check with your healthcare provider about the right way to throw away used syringes and needles. There may be local or state laws about how to throw away used needles and syringes. Do not throw away used needles and syringes in household trash or recycling bins.

The NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® prevents the cartridge from being completely emptied. It is designed to deliver 300 units.

M. Put the pen cap on the NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® and store the NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® without the needle attached (see diagram M).

Put the pen cap on - Illustration

FUNCTION CHECK

If your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® is not working the right way, follow the steps below:

  • Screw on a new NovoFine® needle
  • Remove the big outer needle cap and the inner needle cap
  • Do an airshot as described in &lquo;Giving the airshot before each injection”.
  • Put the big outer needle cap onto the needle. Do not put on the inner needle cap.
  • Turn the dose selector so the dose indicator window shows 20 units.
  • Hold the NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® so the needle is pointing down
  • Press the push-button all the way in.

The insulin should fill the lower part of the big outer needle cap (see diagram N). If NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® has released too much or too little insulin, do the function check again. If the same problem happens again, do not use your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® and contact Novo Nordisk at 1-800-727-6500.

The insulin should fill the lower part of the big outer needle cap - Illustration

Maintenance

Your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® is designed to work accurately and safely. It must be handled with care. Avoid dropping your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® as it may damage it. If you are concerned that your NovoLog® Mix 70/30 FlexPen® is damaged, use a new one. You can clean the outside of your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® by wiping it with a damp cloth. Do not soak or wash your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® as it may damage it. Do not refill your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen®.

  • Remove the needle from the NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® after each injection. This helps to ensure sterility, prevent leakage of insulin, and will help to make sure you inject the right dose of insulin for future injections.
  • Be careful when handling used needles to avoid needle sticks and transfer of infectious diseases.
  • Keep your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® and needles out of the reach of children.
  • Use NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® as directed to treat your diabetes. Do not share it with anyone else even if they also have diabetes.
  • Always use a new needle for each injection.
  • Novo Nordisk is not responsible for harm due to using this insulin pen with products not recommended by Novo Nordisk.
  • As a precautionary measure, always carry a spare insulin delivery device in case your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® is lost or damaged.
  • Remember to keep the disposable NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) FlexPen® with you. Do not leave it in a car or other location where it can get too hot or too cold.

NovoLog®, FlexPen®, NovoFine®, are trademarks of Novo Nordisk A/S.
NovoLog® is covered by US Patent Nos. 5,547,930, 5,618,913, 5,834,422, 5,840,680, 5,866,538 and other patents pending.
FlexPen® is covered by US Patent Nos. 6,582,404, 6,004,297, 6,235,004 and other patents pending.
© 2002-2010 Novo Nordisk Inc.

Manufactured by: Novo Nordisk A/S, DK-2880 Bagsvaerd, Denmark, For information about NovoLog Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) ® contact: Novo Nordisk Inc., 100 College Road West, Princeton, New Jersey 08540

Patient Instructions for Use

NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) 10ml vial (100 Units/mL, U-100)

Read the following Patient Instructions for Use carefully before you start using your NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) 10ml vial and each time you get a refill. There may be new information. You should read the instructions even if you have used NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) 10ml vials before.

Before starting, gather all of the supplies that you will need to use for preparing and giving your insulin injection.

Never re-use syringes and needles.

How should I prepare and deliver the injection using the NovoLog® Mix 70/30 10 ml vial?

  1. Check to make sure you have the correct type of insulin. This is especially important if you use different types of insulin.
  2. Look at the vial and the insulin. The insulin should be white and cloudy after mixing. The tamper-resistant cap should be on the vial before the first use. If the cap has already been removed before your first use of the vial, or if the insulin looks clear or contains any particles, do not use it and return it to your pharmacy.
  3. Wash your hands with soap and water. Clean your injection site with an alcohol swab and let the injection site dry before you inject. Talk with your healthcare provider about how to rotate injection sites and how to give an injection.
  4. If you are using a new vial, pull off the tamper-resistant cap. Wipe the rubber stopper with an alcohol swab.
  5. Roll the vial gently 10 times in your hands to mix it. This should be done with the vial in a horizontal (flat) position between your palms. Do not shake the vial. Shaking right before the dose is drawn into the syringe may cause bubbles or foam. This can cause you to draw up the wrong dose of insulin. The insulin should be used only if it looks white and cloudy.
  6. Pull back the plunger on the syringe until the black tip reaches the marking for the number of units you will inject.
  7. Push the needle through the rubber stopper into the vial, and push the plunger all the way in to force air into the vial.
  8. Turn the vial and syringe upside down and slowly pull the plunger back to a few units beyond the correct dose needed.
  9. If there are air bubbles in the syringe, tap the syringe gently with your finger to raise the air bubbles to the top. Slowly push the plunger to the marking for your dose. This should move any air bubbles in the syringe back into the vial.
  10. Check to make sure you have the right dose of NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) in the syringe.
  11. Pull the syringe out of the vial's rubber stopper.
  12. If there is a delay after you rolled the vial, you will have to roll it again to remix the insulin and redraw your medicine. Your healthcare provider should tell you if you need to pinch the skin before inserting the needle. This can be different from person to person so it is important to ask your doctor if you did not receive instructions on pinching the skin. Insert the needle into the skin right away. Push the plunger to inject the insulin under your skin. Keep the needle under your skin for at least 6 seconds to make sure you have injected all the insulin. When you are finished injecting the insulin, pull the needle out of your skin.
  13. Your may see a drop of NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) at the needle tip. This is normal and has no effect on the dose you just received. If blood appears after you pull the needle from your skin, press the injection site lightly with an alcohol swab. Do not rub the area. Do not recap the needle.
  14. After the injection, dispose of the needle and syringe in a puncture-resistant container. Place used syringes, needles, and insulin vials in a disposable puncture-resistant sharps container, or some type of hard plastic or metal container with a screw on cap such as a detergent bottle or coffee can.
  15. Ask your healthcare provider about the right way to throw away used syringes and needles. There may be state or local laws about the right way to throw away used syringes and needles. Do not throw away used needles and syringes in household trash or recycling bins.

Helpful information for people with diabetes is published by the American Diabetes Association, 1660 Duke Street, Alexandria, VA 22314.

Last reviewed on RxList: 6/9/2010
This monograph has been modified to include the generic and brand name in many instances.

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NovoLog Mix 70/30 - User Reviews

NovoLog Mix 70/30 User Reviews

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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